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Therapeutic effect of korean red ginseng on inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury.

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Title: Therapeutic effect of korean red ginseng on inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury.
Authors: Lee JS (AUTHOR), Choi HS (AUTHOR), Kang SW (AUTHOR), Chung J (AUTHOR), Park HK (AUTHOR), Ban JY (AUTHOR), Kwon OY (AUTHOR), Hong HP (AUTHOR), Ko YG (AUTHOR)
Source: American Journal of Chinese Medicine. 2011, Vol. 39 Issue 1, p83-94. 12p.
Subjects: Therapeutic use of ginseng, Neuroprotective agents, Reperfusion injury, T-test (Statistics), Research funding, Enzyme-linked immunosorbent assay, Questionnaires, Rats, Animal experimentation, Analysis of variance, Ginseng, Cerebral ischemia, Cytokines, Data analysis software, Cerebral circulation, Tumor necrosis factors, Interleukins, Disease complications
Abstract: This study aims to identify the therapeutic effect of Korean red ginseng (KRG) on the expression of inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Adult male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (tMCAO) for two hours. They were fed KRG extract (100 mg/kg/day per orally) or saline after reperfusion. Tests for neurological deficits, using the modified neurologic severity score and the corner turn test, were performed before the ischemic event, and one, three, and seven days after tMCAO. Serum levels of cytokines were measured three and seven days after the operation, using enzyme-linked immunosorbent assays. The infarct volume was assessed after seven days by staining brain tissue with 2% 2, 3, 5-triphenyltetrazolium chloride. Oral administration of KRG significantly reduced the infarct volumes and rapidly improved neurological deficits. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6 were higher in tMCAO-operated rats than in the sham-operated rats. These changes were attenuated by daily KRG intake for seven days. Serum IL-10 levels were significantly increased in KRG-fed rats, as compared to sham-operated and saline-fed rats. Our results suggested that KRG provides neuroprotection for rats with focal cerebral ischemia/reperfusion injury. This neuroprotection may be due to raised IL-10 expression and a reduction in the serum levels of TNF-α, IL-1β, and IL-6. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Therapeutic effect of korean red ginseng on inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Lee+JS%22">Lee JS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi+HS%22">Choi HS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kang+SW%22">Kang SW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung+J%22">Chung J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park+HK%22">Park HK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ban+JY%22">Ban JY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwon+OY%22">Kwon OY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hong+HP%22">Hong HP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ko+YG%22">Ko YG</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2011, Vol. 39 Issue 1, p83-94. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Therapeutic+use+of+ginseng%22">Therapeutic use of ginseng</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroprotective+agents%22">Neuroprotective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Reperfusion+injury%22">Reperfusion injury</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme-linked+immunosorbent+assay%22">Enzyme-linked immunosorbent assay</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Ginseng%22">Ginseng</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+ischemia%22">Cerebral ischemia</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+necrosis+factors%22">Tumor necrosis factors</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukins%22">Interleukins</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study aims to identify the therapeutic effect of Korean red ginseng (KRG) on the expression of inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Adult male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (tMCAO) for two hours. They were fed KRG extract (100 mg/kg/day per orally) or saline after reperfusion. Tests for neurological deficits, using the modified neurologic severity score and the corner turn test, were performed before the ischemic event, and one, three, and seven days after tMCAO. Serum levels of cytokines were measured three and seven days after the operation, using enzyme-linked immunosorbent assays. The infarct volume was assessed after seven days by staining brain tissue with 2% 2, 3, 5-triphenyltetrazolium chloride. Oral administration of KRG significantly reduced the infarct volumes and rapidly improved neurological deficits. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6 were higher in tMCAO-operated rats than in the sham-operated rats. These changes were attenuated by daily KRG intake for seven days. Serum IL-10 levels were significantly increased in KRG-fed rats, as compared to sham-operated and saline-fed rats. Our results suggested that KRG provides neuroprotection for rats with focal cerebral ischemia/reperfusion injury. This neuroprotection may be due to raised IL-10 expression and a reduction in the serum levels of TNF-α, IL-1β, and IL-6. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1142/s0192415x1100866x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 83
    Subjects:
      – SubjectFull: Therapeutic use of ginseng
        Type: general
      – SubjectFull: Neuroprotective agents
        Type: general
      – SubjectFull: Reperfusion injury
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Enzyme-linked immunosorbent assay
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Ginseng
        Type: general
      – SubjectFull: Cerebral ischemia
        Type: general
      – SubjectFull: Cytokines
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Cerebral circulation
        Type: general
      – SubjectFull: Tumor necrosis factors
        Type: general
      – SubjectFull: Interleukins
        Type: general
      – SubjectFull: Disease complications
        Type: general
    Titles:
      – TitleFull: Therapeutic effect of korean red ginseng on inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury.
        Type: main
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          Name:
            NameFull: Lee JS
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          Name:
            NameFull: Choi HS
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            NameFull: Kang SW
      – PersonEntity:
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            NameFull: Chung J
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            NameFull: Park HK
      – PersonEntity:
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            NameFull: Ban JY
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            NameFull: Kwon OY
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            NameFull: Hong HP
      – PersonEntity:
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            NameFull: Ko YG
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            – D: 01
              M: 02
              Text: 2011
              Type: published
              Y: 2011
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              Value: 0192415X
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              Value: 39
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            – TitleFull: American Journal of Chinese Medicine
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