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Acute, reversible axonal energy failure during stroke-like episodes in MELAS.

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Title: Acute, reversible axonal energy failure during stroke-like episodes in MELAS.
Authors: Farrar MA (AUTHOR), Lin CS (AUTHOR), Krishnan AV (AUTHOR), Park SB (AUTHOR), Andrews PI (AUTHOR), Kiernan MC (AUTHOR)
Source: Pediatrics. Sep2010, Vol. 126 Issue 3, pe734-9. 1p.
Abstract: The pathophysiology of stroke-like episodes in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) remains unresolved. Possible mechanisms include mitochondrial angiopathy, cytopathy, or both, collectively resulting in cellular energy depletion. To clarify disease mechanisms, axonal excitability properties were investigated in a 10-year-old child with MELAS. Serial assessments during a stroke-like episode revealed reversible depolarization of the axonal membrane consistent with disruption of energy-dependent processes. Axonal parameters correlated with the clinical assessment of central dysfunction and biochemical measures of acidosis. Novel axonal excitability techniques have established acute, reversible ischemic-like depolarization that may serve as a surrogate marker of central events that develop during stroke-like episodes in MELAS. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 105092316
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Acute, reversible axonal energy failure during stroke-like episodes in MELAS.
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  Data: <searchLink fieldCode="AR" term="%22Farrar+MA%22">Farrar MA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin+CS%22">Lin CS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krishnan+AV%22">Krishnan AV</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park+SB%22">Park SB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andrews+PI%22">Andrews PI</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kiernan+MC%22">Kiernan MC</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Sep2010, Vol. 126 Issue 3, pe734-9. 1p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The pathophysiology of stroke-like episodes in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) remains unresolved. Possible mechanisms include mitochondrial angiopathy, cytopathy, or both, collectively resulting in cellular energy depletion. To clarify disease mechanisms, axonal excitability properties were investigated in a 10-year-old child with MELAS. Serial assessments during a stroke-like episode revealed reversible depolarization of the axonal membrane consistent with disruption of energy-dependent processes. Axonal parameters correlated with the clinical assessment of central dysfunction and biochemical measures of acidosis. Novel axonal excitability techniques have established acute, reversible ischemic-like depolarization that may serve as a surrogate marker of central events that develop during stroke-like episodes in MELAS. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1542/peds.2009-2930
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        Text: English
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