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Smoking-related health risks among persons with HIV in the strategies for management of antiretroviral therapy clinical trial.

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Title: Smoking-related health risks among persons with HIV in the strategies for management of antiretroviral therapy clinical trial.
Authors: Lifson AR (AUTHOR), Neuhaus J (AUTHOR), Arribas JR (AUTHOR), van den Berg-Wolf M (AUTHOR), Labriola AM (AUTHOR), Read TR (AUTHOR), INSIGHT SMART Study Group (CORPORATE AUTHOR)
Source: American Journal of Public Health. Oct2010, Vol. 100 Issue 10, p1896-1903. 8p.
Subjects: HIV-positive persons, Smoking, Health, Clinical trials, Antiretroviral agents, AIDS epidemiology, Disease incidence
Abstract: OBJECTIVES: We sought to determine smoking-related hazard ratios (HRs) and population-attributable risk percentage (PAR%) for serious clinical events and death among HIV-positive persons, whose smoking prevalence is higher than in the general population. METHODS: For 5472 HIV-infected persons enrolled from 33 countries in the Strategies for Management of Antiretroviral Therapy clinical trial, we evaluated the relationship between baseline smoking status and development of AIDS-related or serious non-AIDS events and overall mortality. RESULTS: Among all participants, 40.5% were current smokers and 24.8% were former smokers. Adjusted HRs were higher for current than for never smokers for overall mortality (2.4; P < .001), major cardiovascular disease (2.0; P = .002), non-AIDS cancer (1.8; P = .008), and bacterial pneumonia (2.3; P < .001). Adjusted HRs also were significantly higher for these outcomes among current than among former smokers. The PAR% for current versus former and never smokers combined was 24.3% for overall mortality, 25.3% for major cardiovascular disease, 30.6% for non-AIDS cancer, and 25.4% for bacterial pneumonia. CONCLUSIONS: Smoking contributes to substantial morbidity and mortality in this HIV-infected population. Providers should routinely integrate smoking cessation programs into HIV health care. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Smoking-related health risks among persons with HIV in the strategies for management of antiretroviral therapy clinical trial.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lifson+AR%22&quot;&gt;Lifson AR&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Neuhaus+J%22&quot;&gt;Neuhaus J&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Arribas+JR%22&quot;&gt;Arribas JR&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22van+den+Berg-Wolf+M%22&quot;&gt;van den Berg-Wolf M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Labriola+AM%22&quot;&gt;Labriola AM&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Read+TR%22&quot;&gt;Read TR&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22INSIGHT+SMART+Study+Group%22&quot;&gt;INSIGHT SMART Study Group&lt;/searchLink&gt; (CORPORATE AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22American+Journal+of+Public+Health%22&quot;&gt;American Journal of Public Health&lt;/searchLink&gt;. Oct2010, Vol. 100 Issue 10, p1896-1903. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HIV-positive+persons%22&quot;&gt;HIV-positive persons&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Smoking%22&quot;&gt;Smoking&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Health%22&quot;&gt;Health&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Clinical+trials%22&quot;&gt;Clinical trials&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Antiretroviral+agents%22&quot;&gt;Antiretroviral agents&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22AIDS+epidemiology%22&quot;&gt;AIDS epidemiology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+incidence%22&quot;&gt;Disease incidence&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: OBJECTIVES: We sought to determine smoking-related hazard ratios (HRs) and population-attributable risk percentage (PAR%) for serious clinical events and death among HIV-positive persons, whose smoking prevalence is higher than in the general population. METHODS: For 5472 HIV-infected persons enrolled from 33 countries in the Strategies for Management of Antiretroviral Therapy clinical trial, we evaluated the relationship between baseline smoking status and development of AIDS-related or serious non-AIDS events and overall mortality. RESULTS: Among all participants, 40.5% were current smokers and 24.8% were former smokers. Adjusted HRs were higher for current than for never smokers for overall mortality (2.4; P &lt; .001), major cardiovascular disease (2.0; P = .002), non-AIDS cancer (1.8; P = .008), and bacterial pneumonia (2.3; P &lt; .001). Adjusted HRs also were significantly higher for these outcomes among current than among former smokers. The PAR% for current versus former and never smokers combined was 24.3% for overall mortality, 25.3% for major cardiovascular disease, 30.6% for non-AIDS cancer, and 25.4% for bacterial pneumonia. CONCLUSIONS: Smoking contributes to substantial morbidity and mortality in this HIV-infected population. Providers should routinely integrate smoking cessation programs into HIV health care. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105102218
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.2105/AJPH.2009.188664
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 1896
    Subjects:
      – SubjectFull: HIV-positive persons
        Type: general
      – SubjectFull: Smoking
        Type: general
      – SubjectFull: Health
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Antiretroviral agents
        Type: general
      – SubjectFull: AIDS epidemiology
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      – SubjectFull: Disease incidence
        Type: general
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      – TitleFull: Smoking-related health risks among persons with HIV in the strategies for management of antiretroviral therapy clinical trial.
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              Text: Oct2010
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              Y: 2010
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