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A sham-controlled trial of left and right temporal rTMS for the treatment of auditory hallucinations.

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Title: A sham-controlled trial of left and right temporal rTMS for the treatment of auditory hallucinations.
Authors: Loo CK (AUTHOR), Sainsbury K (AUTHOR), Mitchell P (AUTHOR), Hadzi-Pavlovic D (AUTHOR), Sachdev PS (AUTHOR)
Source: Psychological Medicine. Apr2010, Vol. 40 Issue 4, p541-546. 6p.
Abstract: BACKGROUND: Several studies have reported reduction of auditory hallucinations (AH) after repetitive transcranial magnetic stimulation (rTMS) to the left temporal cortex. This study explored the effects of rTMS to the left and right temporal cortex. METHOD: Eighteen subjects with schizophrenia and frequent AH were enrolled in a double-blind, cross-over trial of 3 days of active rTMS to the left or right temporal cortex, or sham rTMS to the vertex (control condition), followed by an open treatment phase. The effects on AH were assessed by a blinded rater, using the Auditory Hallucination Rating Scale (AHRS). RESULTS: During the double-blind phase, active temporal rTMS did not result in significantly greater improvement in hallucination scores than sham rTMS to the vertex, apart from a reduction in distress scores. Hallucination scores improved during the open continued treatment phase. CONCLUSIONS: This study did not demonstrate an advantage for left temporal rTMS compared to right temporal and sham stimulation, over a 3-day stimulation period, but found modest improvement in hallucinations during continued open label treatment. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A sham-controlled trial of left and right temporal rTMS for the treatment of auditory hallucinations.
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  Data: <searchLink fieldCode="AR" term="%22Loo+CK%22">Loo CK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sainsbury+K%22">Sainsbury K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mitchell+P%22">Mitchell P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hadzi-Pavlovic+D%22">Hadzi-Pavlovic D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sachdev+PS%22">Sachdev PS</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Apr2010, Vol. 40 Issue 4, p541-546. 6p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Several studies have reported reduction of auditory hallucinations (AH) after repetitive transcranial magnetic stimulation (rTMS) to the left temporal cortex. This study explored the effects of rTMS to the left and right temporal cortex. METHOD: Eighteen subjects with schizophrenia and frequent AH were enrolled in a double-blind, cross-over trial of 3 days of active rTMS to the left or right temporal cortex, or sham rTMS to the vertex (control condition), followed by an open treatment phase. The effects on AH were assessed by a blinded rater, using the Auditory Hallucination Rating Scale (AHRS). RESULTS: During the double-blind phase, active temporal rTMS did not result in significantly greater improvement in hallucination scores than sham rTMS to the vertex, apart from a reduction in distress scores. Hallucination scores improved during the open continued treatment phase. CONCLUSIONS: This study did not demonstrate an advantage for left temporal rTMS compared to right temporal and sham stimulation, over a 3-day stimulation period, but found modest improvement in hallucinations during continued open label treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Apr2010
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