Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats.
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| Title: | Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats. |
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| Authors: | Huang Y (AUTHOR), Li J (AUTHOR), Meng XM (AUTHOR), Jiang GL (AUTHOR), Li H (AUTHOR), Cao Q (AUTHOR), Yu SC (AUTHOR), Lv XW (AUTHOR), Cheng WM (AUTHOR) |
| Source: | American Journal of Chinese Medicine. 2009, Vol. 37 Issue 6, p1099-1111. 13p. |
| Abstract: | The goal of this study was to investigate the possible therapy mechanism of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf (TAL) in alveolar macrophage (AM) of chronic bronchitis (CB) rats. CB model was established by injection of bacillus calmette guein (BCG) plus lipopolisacharide (LPS) in rats. TAL significantly inhibited the increased NO concentration, iNOS expression and phosphorylation of p38 MAPK in alveolar macrophages (AMs) of CB rats. Using in vivo test, we found that SB203580, a p38 MAPK inhibitor, (10 muM) significantly inhibited inducible nitric oxide synthase (iNOS) mRNA expression in AM. This data indicate that TAL highly decreases excessive iNOS expression and NO induction, and p38 MAPK signal transduction participates in iNOS expression and NO induction in AM of CB rats. The effect of TAL on iNOS expression in AM may be related to its inhibition of p38 MAPK signal transduction. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105253900 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Huang+Y%22">Huang Y</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li+J%22">Li J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meng+XM%22">Meng XM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang+GL%22">Jiang GL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li+H%22">Li H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao+Q%22">Cao Q</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu+SC%22">Yu SC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lv+XW%22">Lv XW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng+WM%22">Cheng WM</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2009, Vol. 37 Issue 6, p1099-1111. 13p. – Name: Abstract Label: Abstract Group: Ab Data: The goal of this study was to investigate the possible therapy mechanism of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf (TAL) in alveolar macrophage (AM) of chronic bronchitis (CB) rats. CB model was established by injection of bacillus calmette guein (BCG) plus lipopolisacharide (LPS) in rats. TAL significantly inhibited the increased NO concentration, iNOS expression and phosphorylation of p38 MAPK in alveolar macrophages (AMs) of CB rats. Using in vivo test, we found that SB203580, a p38 MAPK inhibitor, (10 muM) significantly inhibited inducible nitric oxide synthase (iNOS) mRNA expression in AM. This data indicate that TAL highly decreases excessive iNOS expression and NO induction, and p38 MAPK signal transduction participates in iNOS expression and NO induction in AM of CB rats. The effect of TAL on iNOS expression in AM may be related to its inhibition of p38 MAPK signal transduction. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1142/s0192415x09007521 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1099 Titles: – TitleFull: Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Huang Y – PersonEntity: Name: NameFull: Li J – PersonEntity: Name: NameFull: Meng XM – PersonEntity: Name: NameFull: Jiang GL – PersonEntity: Name: NameFull: Li H – PersonEntity: Name: NameFull: Cao Q – PersonEntity: Name: NameFull: Yu SC – PersonEntity: Name: NameFull: Lv XW – PersonEntity: Name: NameFull: Cheng WM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 0192415X Numbering: – Type: volume Value: 37 – Type: issue Value: 6 Titles: – TitleFull: American Journal of Chinese Medicine Type: main |
| ResultId | 1 |
