13C-sucrose breath test: novel use of a noninvasive biomarker of environmental gut health.
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| Title: | 13C-sucrose breath test: novel use of a noninvasive biomarker of environmental gut health. |
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| Authors: | Ritchie BK (AUTHOR), Brewster DR (AUTHOR), Davidson GP (AUTHOR), Tran CD (AUTHOR), McNeil Y (AUTHOR), Hawkes JS (AUTHOR), Butler RN (AUTHOR) |
| Source: | Pediatrics. Aug2009, Vol. 124 Issue 2, p620-626. 7p. |
| Abstract: | OBJECTIVE: Environmental enteropathy syndrome may compromise growth and predispose to infectious diseases in children in the developing world, including Australian Aboriginal children from remote communities of the Northern Territory. In this study, we described the use of a biomarker (13)C-sucrose breath test (SBT) to measure enterocyte sucrase activity as a marker of small intestinal villus integrity and function. METHODS: This was a hospital-based prospective case-control study of Aboriginal and non-Aboriginal children with and without acute diarrheal disease. Using the SBT, we compared 36 Aboriginal case subjects admitted to a hospital (18 diarrheal and 18 nondiarrheal disease), with 7 healthy non-Aboriginal control subjects. Intestinal permeability using the lactulose/rhamnose (L/R) ratio on a timed 90-minute blood test was performed simultaneously with the SBT. The SBT results are expressed as a cumulative percentage of the dose recovered at 90 minutes. RESULTS: Aboriginal children with acute diarrheal disease have a significantly decreased absorptive capacity, as determined by the SBT, with a mean of 1.9% compared with either Aboriginal children without diarrhea (4.1%) or non-Aboriginal (6.1%) control subjects. The mean L/R ratio in the diarrhea group was 31.8 compared with 11.4 in Aboriginal children without diarrhea. There was a significant inverse correlation between the SBT and the L/R ratio. CONCLUSIONS: The SBT was able to discriminate among Aboriginal children with diarrhea, asymptomatic Aboriginal children with an underlying environmental enteropathy, and healthy non-Aboriginal controls. This test provides a noninvasive, easy-to-use, integrated marker of the absorptive capacity and integrity of the small intestine and could be a valuable tool in evaluating the efficacy of interventions aimed at improving gut health. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105421619 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: 13C-sucrose breath test: novel use of a noninvasive biomarker of environmental gut health. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ritchie+BK%22">Ritchie BK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brewster+DR%22">Brewster DR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Davidson+GP%22">Davidson GP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tran+CD%22">Tran CD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McNeil+Y%22">McNeil Y</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hawkes+JS%22">Hawkes JS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Butler+RN%22">Butler RN</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Aug2009, Vol. 124 Issue 2, p620-626. 7p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVE: Environmental enteropathy syndrome may compromise growth and predispose to infectious diseases in children in the developing world, including Australian Aboriginal children from remote communities of the Northern Territory. In this study, we described the use of a biomarker (13)C-sucrose breath test (SBT) to measure enterocyte sucrase activity as a marker of small intestinal villus integrity and function. METHODS: This was a hospital-based prospective case-control study of Aboriginal and non-Aboriginal children with and without acute diarrheal disease. Using the SBT, we compared 36 Aboriginal case subjects admitted to a hospital (18 diarrheal and 18 nondiarrheal disease), with 7 healthy non-Aboriginal control subjects. Intestinal permeability using the lactulose/rhamnose (L/R) ratio on a timed 90-minute blood test was performed simultaneously with the SBT. The SBT results are expressed as a cumulative percentage of the dose recovered at 90 minutes. RESULTS: Aboriginal children with acute diarrheal disease have a significantly decreased absorptive capacity, as determined by the SBT, with a mean of 1.9% compared with either Aboriginal children without diarrhea (4.1%) or non-Aboriginal (6.1%) control subjects. The mean L/R ratio in the diarrhea group was 31.8 compared with 11.4 in Aboriginal children without diarrhea. There was a significant inverse correlation between the SBT and the L/R ratio. CONCLUSIONS: The SBT was able to discriminate among Aboriginal children with diarrhea, asymptomatic Aboriginal children with an underlying environmental enteropathy, and healthy non-Aboriginal controls. This test provides a noninvasive, easy-to-use, integrated marker of the absorptive capacity and integrity of the small intestine and could be a valuable tool in evaluating the efficacy of interventions aimed at improving gut health. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105421619 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2008-2257 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 620 Titles: – TitleFull: 13C-sucrose breath test: novel use of a noninvasive biomarker of environmental gut health. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ritchie BK – PersonEntity: Name: NameFull: Brewster DR – PersonEntity: Name: NameFull: Davidson GP – PersonEntity: Name: NameFull: Tran CD – PersonEntity: Name: NameFull: McNeil Y – PersonEntity: Name: NameFull: Hawkes JS – PersonEntity: Name: NameFull: Butler RN IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 124 – Type: issue Value: 2 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
