View in EDS PDF Full Text

Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC)

Saved in:
Bibliographic Details
Title: Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC)
Authors: Reiter R (AUTHOR), Gais P (AUTHOR), Steuer-Vogt MK (AUTHOR), Boulesteix A (AUTHOR), Deutschle T (AUTHOR), Hampel R (AUTHOR), Wagenpfeil S (AUTHOR), Rauser S (AUTHOR), Walch A (AUTHOR), Bink K (AUTHOR), Jütting U (AUTHOR), Neff F (AUTHOR), Arnold W (AUTHOR), Höfler H (AUTHOR), Pickhard A (AUTHOR)
Source: Acta Oto-Laryngologica. Feb2009, Vol. 129 Issue 2, p205-213. 9p.
Abstract: Conclusions. Numerical and structural centrosome abnormalities play a critical role in the tumor progression of in head and neck squamous cell carcinoma (HNSCC) and may provide useful information as a prognostic factor for these patients. Objectives. Centrosome alterations are often linked with aneuploidy, cell transformation, and tumor progress. We investigated centrosome abnormalities in HNSCC and correlated these variables to clinicopathological parameters and clinical follow up data of the patients. Methods. Retrospective analysis of numerical and structural alterations of centrosomes in tumor tissues and corresponding normal epithelium (n=50 and 31, respectively). Immunohistochemistry was performed using an anti-[gamma]-tubulin antibody. Image acquisition was done by an Orthoplan microscope, centrosomes were segmented interactively, and area as well as mean optical density was measured. Aneuploidy was evaluated by fluorescence in situ hybridization in a subset of cases (n=29). Results. Numerical and structural centrosome abnormalities differed significantly between normal squamous epithelium and tumor cells (both P<0.0001). Especially numerical centrosome abnormalities were significantly associated with T category and tumor stage (both P<0.0001) and the occurrence of distant metastasis (P=0.002 and P=0.019, respectively). Numerical centrosome abnormalities correlated also with disease free survival of the patients (P=0.032) as well as shorter overall survival (P=0.003). [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 105450186
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC)
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reiter+R%22&quot;&gt;Reiter R&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gais+P%22&quot;&gt;Gais P&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Steuer-Vogt+MK%22&quot;&gt;Steuer-Vogt MK&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Boulesteix+A%22&quot;&gt;Boulesteix A&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Deutschle+T%22&quot;&gt;Deutschle T&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hampel+R%22&quot;&gt;Hampel R&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wagenpfeil+S%22&quot;&gt;Wagenpfeil S&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rauser+S%22&quot;&gt;Rauser S&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Walch+A%22&quot;&gt;Walch A&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bink+K%22&quot;&gt;Bink K&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22J&#252;tting+U%22&quot;&gt;J&#252;tting U&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Neff+F%22&quot;&gt;Neff F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Arnold+W%22&quot;&gt;Arnold W&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22H&#246;fler+H%22&quot;&gt;H&#246;fler H&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pickhard+A%22&quot;&gt;Pickhard A&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Oto-Laryngologica%22&quot;&gt;Acta Oto-Laryngologica&lt;/searchLink&gt;. Feb2009, Vol. 129 Issue 2, p205-213. 9p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Conclusions. Numerical and structural centrosome abnormalities play a critical role in the tumor progression of in head and neck squamous cell carcinoma (HNSCC) and may provide useful information as a prognostic factor for these patients. Objectives. Centrosome alterations are often linked with aneuploidy, cell transformation, and tumor progress. We investigated centrosome abnormalities in HNSCC and correlated these variables to clinicopathological parameters and clinical follow up data of the patients. Methods. Retrospective analysis of numerical and structural alterations of centrosomes in tumor tissues and corresponding normal epithelium (n=50 and 31, respectively). Immunohistochemistry was performed using an anti-[gamma]-tubulin antibody. Image acquisition was done by an Orthoplan microscope, centrosomes were segmented interactively, and area as well as mean optical density was measured. Aneuploidy was evaluated by fluorescence in situ hybridization in a subset of cases (n=29). Results. Numerical and structural centrosome abnormalities differed significantly between normal squamous epithelium and tumor cells (both P&lt;0.0001). Especially numerical centrosome abnormalities were significantly associated with T category and tumor stage (both P&lt;0.0001) and the occurrence of distant metastasis (P=0.002 and P=0.019, respectively). Numerical centrosome abnormalities correlated also with disease free survival of the patients (P=0.032) as well as shorter overall survival (P=0.003). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Acta Oto-Laryngologica is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105450186
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016480802165767
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 205
    Titles:
      – TitleFull: Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC)
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Reiter R
      – PersonEntity:
          Name:
            NameFull: Gais P
      – PersonEntity:
          Name:
            NameFull: Steuer-Vogt MK
      – PersonEntity:
          Name:
            NameFull: Boulesteix A
      – PersonEntity:
          Name:
            NameFull: Deutschle T
      – PersonEntity:
          Name:
            NameFull: Hampel R
      – PersonEntity:
          Name:
            NameFull: Wagenpfeil S
      – PersonEntity:
          Name:
            NameFull: Rauser S
      – PersonEntity:
          Name:
            NameFull: Walch A
      – PersonEntity:
          Name:
            NameFull: Bink K
      – PersonEntity:
          Name:
            NameFull: Jütting U
      – PersonEntity:
          Name:
            NameFull: Neff F
      – PersonEntity:
          Name:
            NameFull: Arnold W
      – PersonEntity:
          Name:
            NameFull: Höfler H
      – PersonEntity:
          Name:
            NameFull: Pickhard A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2009
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 00016489
          Numbering:
            – Type: volume
              Value: 129
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Acta Oto-Laryngologica
              Type: main
ResultId 1