Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment.
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| Title: | Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment. |
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| Authors: | Johnson SC (AUTHOR), Schmitz TW (AUTHOR), Asthana S (AUTHOR), Gluck MA (AUTHOR), Myers C (AUTHOR), Johnson, Sterling C (AUTHOR), Schmitz, Taylor W (AUTHOR), Asthana, Sanjay (AUTHOR), Gluck, Mark A (AUTHOR), Myers, Catherine (AUTHOR) |
| Source: | Aging, Neuropsychology & Cognition. Mar2008, Vol. 15 Issue 2, p129-145. 17p. |
| Abstract: | The ability to form associations between choice alternatives and their contingent outcomes is an important aspect of learning that may be sensitive to hippocampal dysfunction in memory disorders of aging such as amnestic mild cognitive impairment (MCIa), or early Alzheimer disease. In this preliminary study we examined brain activation using functional magnetic resonance imaging (fMRI) in 12 healthy elderly participants and nine patients with MCIa during an associative learning task. Using a high-field 3.0-Tesla MRI scanner, we examined the dynamic neural response during associative learning over trials. The slope of signal attenuation associated with learning was analyzed for differences between groups within an a priori defined hippocampal region. Results indicated dynamic signal attenuation associated with learning in the healthy elderly sample, but not in MCIa. The absence of an associative learning effect in the MCIa sample reaffirms an important link between the learning difficulties that are commonly encountered in MCIa and the mesial temporal region. [ABSTRACT FROM AUTHOR] |
| Copyright of Aging, Neuropsychology & Cognition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105455630 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Johnson+SC%22">Johnson SC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmitz+TW%22">Schmitz TW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asthana+S%22">Asthana S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gluck+MA%22">Gluck MA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Myers+C%22">Myers C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Johnson%2C+Sterling+C%22">Johnson, Sterling C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmitz%2C+Taylor+W%22">Schmitz, Taylor W</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asthana%2C+Sanjay%22">Asthana, Sanjay</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gluck%2C+Mark+A%22">Gluck, Mark A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Myers%2C+Catherine%22">Myers, Catherine</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Aging%2C+Neuropsychology+%26+Cognition%22">Aging, Neuropsychology & Cognition</searchLink>. Mar2008, Vol. 15 Issue 2, p129-145. 17p. – Name: Abstract Label: Abstract Group: Ab Data: The ability to form associations between choice alternatives and their contingent outcomes is an important aspect of learning that may be sensitive to hippocampal dysfunction in memory disorders of aging such as amnestic mild cognitive impairment (MCIa), or early Alzheimer disease. In this preliminary study we examined brain activation using functional magnetic resonance imaging (fMRI) in 12 healthy elderly participants and nine patients with MCIa during an associative learning task. Using a high-field 3.0-Tesla MRI scanner, we examined the dynamic neural response during associative learning over trials. The slope of signal attenuation associated with learning was analyzed for differences between groups within an a priori defined hippocampal region. Results indicated dynamic signal attenuation associated with learning in the healthy elderly sample, but not in MCIa. The absence of an associative learning effect in the MCIa sample reaffirms an important link between the learning difficulties that are commonly encountered in MCIa and the mesial temporal region. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Aging, Neuropsychology & Cognition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105455630 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/13825580601139444 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 129 Titles: – TitleFull: Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Johnson SC – PersonEntity: Name: NameFull: Schmitz TW – PersonEntity: Name: NameFull: Asthana S – PersonEntity: Name: NameFull: Gluck MA – PersonEntity: Name: NameFull: Myers C – PersonEntity: Name: NameFull: Johnson, Sterling C – PersonEntity: Name: NameFull: Schmitz, Taylor W – PersonEntity: Name: NameFull: Asthana, Sanjay – PersonEntity: Name: NameFull: Gluck, Mark A – PersonEntity: Name: NameFull: Myers, Catherine IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 13825585 Numbering: – Type: volume Value: 15 – Type: issue Value: 2 Titles: – TitleFull: Aging, Neuropsychology & Cognition Type: main |
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