Effects of 17ß-estradiol on synaptic plasticity in the rat medial vestibular nuclei.
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| Title: | Effects of 17ß-estradiol on synaptic plasticity in the rat medial vestibular nuclei. |
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| Authors: | Grassi S (AUTHOR), Frondaroli A (AUTHOR), Dieni C (AUTHOR), Scarduzio M (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Apr2009, Vol. 129 Issue 4, p390-394. 5p. |
| Abstract: | CONCLUSION: This study shows that 17beta-estradiol (E(2)) can amplify the long-term potentiation (LTP) induced in the vestibular nuclei by high frequency stimulation (HFS), while potentiation induced by E(2) alone, which is unrelated to synaptic high frequency activation, is reversed by HFS. OBJECTIVE: Like HFS, exogenous E(2) induces long-lasting enhancement of synaptic responses to vestibular afferent stimulation in the medial vestibular nuclei (MVN), through NMDA receptor activation. The aim of this study was to verify the possible interaction of E(2) and HFS in inducing LTP. MATERIALS AND METHODS: In rat brainstem slices, we analysed the modifications induced in the field potential evoked in the MVN by: 1) HFS delivered after induction of E(2) effect and 2) E(2) applied after induction of HFS-LTP. RESULTS: HFS reversed the E(2)-induced potentiation in most cases, while E(2) was able to increase the magnitude of potentiation induced by HFS. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105494736 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of 17ß-estradiol on synaptic plasticity in the rat medial vestibular nuclei. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Grassi+S%22">Grassi S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frondaroli+A%22">Frondaroli A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dieni+C%22">Dieni C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scarduzio+M%22">Scarduzio M</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Apr2009, Vol. 129 Issue 4, p390-394. 5p. – Name: Abstract Label: Abstract Group: Ab Data: CONCLUSION: This study shows that 17beta-estradiol (E(2)) can amplify the long-term potentiation (LTP) induced in the vestibular nuclei by high frequency stimulation (HFS), while potentiation induced by E(2) alone, which is unrelated to synaptic high frequency activation, is reversed by HFS. OBJECTIVE: Like HFS, exogenous E(2) induces long-lasting enhancement of synaptic responses to vestibular afferent stimulation in the medial vestibular nuclei (MVN), through NMDA receptor activation. The aim of this study was to verify the possible interaction of E(2) and HFS in inducing LTP. MATERIALS AND METHODS: In rat brainstem slices, we analysed the modifications induced in the field potential evoked in the MVN by: 1) HFS delivered after induction of E(2) effect and 2) E(2) applied after induction of HFS-LTP. RESULTS: HFS reversed the E(2)-induced potentiation in most cases, while E(2) was able to increase the magnitude of potentiation induced by HFS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105494736 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00016480802566287 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 390 Titles: – TitleFull: Effects of 17ß-estradiol on synaptic plasticity in the rat medial vestibular nuclei. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Grassi S – PersonEntity: Name: NameFull: Frondaroli A – PersonEntity: Name: NameFull: Dieni C – PersonEntity: Name: NameFull: Scarduzio M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00016489 Numbering: – Type: volume Value: 129 – Type: issue Value: 4 Titles: – TitleFull: Acta Oto-Laryngologica Type: main |
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