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Widely varying TNF-alpha levels in patients with myasthenia gravis.

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Title: Widely varying TNF-alpha levels in patients with myasthenia gravis.
Authors: Lee JS (AUTHOR), Joo IS (AUTHOR), Seok JI (AUTHOR), Lee, Jin Soo (AUTHOR), Joo, In Soo (AUTHOR), Seok, Jung Im (AUTHOR)
Source: Neurological Sciences. Jun2009, Vol. 30 Issue 3, p259-262. 4p.
Abstract: Animal studies have indicated an important role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of myasthenia gravis (MG), and trials of monoclonal antibodies that block TNF-alpha have shown clinical improvement. However, before a TNF-alpha blocking agent is proposed for treatment of MG, whether serum TNF-alpha level correlates with the patient's condition should be confirmed. Therefore, we evaluated the relationship between the serum TNF-alpha level and clinical factors, including the quantitative MG score and the anti-acetylcholine receptor antibody level, in 33 MG patients. TNF-alpha levels ranged from 0.44 to 3.63 pg/mL and did not correlate with clinical factors. Overall, we found that serum TNF-alpha levels varied greatly among MG patients. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Widely varying TNF-alpha levels in patients with myasthenia gravis.
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  Data: <searchLink fieldCode="AR" term="%22Lee+JS%22">Lee JS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Joo+IS%22">Joo IS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seok+JI%22">Seok JI</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jin+Soo%22">Lee, Jin Soo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Joo%2C+In+Soo%22">Joo, In Soo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seok%2C+Jung+Im%22">Seok, Jung Im</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jun2009, Vol. 30 Issue 3, p259-262. 4p.
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  Data: Animal studies have indicated an important role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of myasthenia gravis (MG), and trials of monoclonal antibodies that block TNF-alpha have shown clinical improvement. However, before a TNF-alpha blocking agent is proposed for treatment of MG, whether serum TNF-alpha level correlates with the patient's condition should be confirmed. Therefore, we evaluated the relationship between the serum TNF-alpha level and clinical factors, including the quantitative MG score and the anti-acetylcholine receptor antibody level, in 33 MG patients. TNF-alpha levels ranged from 0.44 to 3.63 pg/mL and did not correlate with clinical factors. Overall, we found that serum TNF-alpha levels varied greatly among MG patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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