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Neurotrophic factors in neurodegenerative disorders : potential for therapy.

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Title: Neurotrophic factors in neurodegenerative disorders : potential for therapy.
Authors: Fumagalli F (AUTHOR), Molteni R (AUTHOR), Calabrese F (AUTHOR), Maj PF (AUTHOR), Racagni G (AUTHOR), Riva MA (AUTHOR), Fumagalli, Fabio (AUTHOR), Molteni, Raffaella (AUTHOR), Calabrese, Francesca (AUTHOR), Maj, Paola Francesca (AUTHOR), Racagni, Giorgio (AUTHOR), Riva, Marco Andrea (AUTHOR)
Source: CNS Drugs. 2008, Vol. 22 Issue 12, p1005-1019. 15p.
Abstract: Finding an effective therapy to treat chronic neurodegenerative disorders still represents an unmet and elusive goal, mainly because so many pathogenic variables come into play in these diseases. Recent emphasis has been placed on the role of neurotrophic factors in the aetiology of such disorders because of their role in the survival of different cell phenotypes under various adverse conditions, including neurodegeneration.This review summarizes the current status and the efforts to treat neurodegenerative disorders by the exogenous administration of neurotrophic factors in an attempt to replenish trophic supply, the paucity of which may contribute to the development of the illness. Although promising results have been seen in animal models, this approach still meets disparate and often insurmountable problems in clinical settings, presumably related to the unique nature of the human being. [ABSTRACT FROM AUTHOR]
Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Fumagalli+F%22">Fumagalli F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Molteni+R%22">Molteni R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Calabrese+F%22">Calabrese F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maj+PF%22">Maj PF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Racagni+G%22">Racagni G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riva+MA%22">Riva MA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fumagalli%2C+Fabio%22">Fumagalli, Fabio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Molteni%2C+Raffaella%22">Molteni, Raffaella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Calabrese%2C+Francesca%22">Calabrese, Francesca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maj%2C+Paola+Francesca%22">Maj, Paola Francesca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Racagni%2C+Giorgio%22">Racagni, Giorgio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riva%2C+Marco+Andrea%22">Riva, Marco Andrea</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22CNS+Drugs%22">CNS Drugs</searchLink>. 2008, Vol. 22 Issue 12, p1005-1019. 15p.
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  Data: Finding an effective therapy to treat chronic neurodegenerative disorders still represents an unmet and elusive goal, mainly because so many pathogenic variables come into play in these diseases. Recent emphasis has been placed on the role of neurotrophic factors in the aetiology of such disorders because of their role in the survival of different cell phenotypes under various adverse conditions, including neurodegeneration.This review summarizes the current status and the efforts to treat neurodegenerative disorders by the exogenous administration of neurotrophic factors in an attempt to replenish trophic supply, the paucity of which may contribute to the development of the illness. Although promising results have been seen in animal models, this approach still meets disparate and often insurmountable problems in clinical settings, presumably related to the unique nature of the human being. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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