Protective effect of Rehmannia glutinosa on the UV-induced apoptosis in U937 cells.
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| Title: | Protective effect of Rehmannia glutinosa on the UV-induced apoptosis in U937 cells. |
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| Authors: | Shin SW (AUTHOR), Park CI (AUTHOR), Yang CH (AUTHOR), Park J (AUTHOR) |
| Source: | American Journal of Chinese Medicine. 2008, Vol. 36 Issue 6, p1159-1170. 12p. |
| Abstract: | Ultraviolet (UV) radiation has been shown to generate reactive oxygen species (ROS), such as singlet oxygen, superoxide radicals, hydroxyl radicals and hydrogen peroxide in a variety of cells. These ROS have the potential to damage critical cellular components such as DNA, proteins, and lipids and eventually result in physical and chemical damage to tissues that may lead to cell death. The steamed root of Rehmannia glutinosa (Saeng Jihuang, SJH) is reported to have an antioxidant activity. We investigated the effect of SJH on UV-induced apoptosis in U937 cells. Upon exposure to UV, there was a distinct difference between untreated cells and cells pre-treated with 0.5-2 mg/ml SJH for 12 hours in regard to cellular redox status and morphological change to cells. SJH pre-treated cells showed significant suppression of apoptotic features such as DNA fragmentation, damage to mitochondrial function, and modulation of apoptotic marker proteins upon exposure to UV. This study indicates that SJH may play an important role in regulating the apoptosis induced by UV presumably through scavenging of reactive oxygen species. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105588030 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Protective effect of Rehmannia glutinosa on the UV-induced apoptosis in U937 cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shin+SW%22">Shin SW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park+CI%22">Park CI</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang+CH%22">Yang CH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park+J%22">Park J</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2008, Vol. 36 Issue 6, p1159-1170. 12p. – Name: Abstract Label: Abstract Group: Ab Data: Ultraviolet (UV) radiation has been shown to generate reactive oxygen species (ROS), such as singlet oxygen, superoxide radicals, hydroxyl radicals and hydrogen peroxide in a variety of cells. These ROS have the potential to damage critical cellular components such as DNA, proteins, and lipids and eventually result in physical and chemical damage to tissues that may lead to cell death. The steamed root of Rehmannia glutinosa (Saeng Jihuang, SJH) is reported to have an antioxidant activity. We investigated the effect of SJH on UV-induced apoptosis in U937 cells. Upon exposure to UV, there was a distinct difference between untreated cells and cells pre-treated with 0.5-2 mg/ml SJH for 12 hours in regard to cellular redox status and morphological change to cells. SJH pre-treated cells showed significant suppression of apoptotic features such as DNA fragmentation, damage to mitochondrial function, and modulation of apoptotic marker proteins upon exposure to UV. This study indicates that SJH may play an important role in regulating the apoptosis induced by UV presumably through scavenging of reactive oxygen species. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1142/s0192415x08006491 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1159 Titles: – TitleFull: Protective effect of Rehmannia glutinosa on the UV-induced apoptosis in U937 cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shin SW – PersonEntity: Name: NameFull: Park CI – PersonEntity: Name: NameFull: Yang CH – PersonEntity: Name: NameFull: Park J IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 0192415X Numbering: – Type: volume Value: 36 – Type: issue Value: 6 Titles: – TitleFull: American Journal of Chinese Medicine Type: main |
| ResultId | 1 |
