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Sex differences in systolic heart failure in the elderly: the prognostic importance of left ventricular mass in women.

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Bibliographic Details
Title: Sex differences in systolic heart failure in the elderly: the prognostic importance of left ventricular mass in women.
Authors: Mejhert M (AUTHOR), Kahan T (AUTHOR), Edner M (AUTHOR), Persson HE (AUTHOR)
Source: Journal of Women's Health (15409996). Apr2008, Vol. 17 Issue 3, p373-381. 9p.
Subjects: Hypothesis, Sex differences (Biology), Sex (Biology), Cardiac contraction, Prognostic tests, Prognosis, Heart failure
Abstract: Hypothesis: We investigated the hypothesis that there are prognostic differences in the importance of left ventricular (LV) mass and function between male and female patients hospitalized with heart failure. Methods: Patients >=60 years old hospitalized with New York Heart Association class II-IV heart failure and LV systolic dysfunction were prospectively followed for >=18 months. At study start, a physical examination and echocardiography were performed, and blood chemistry samples were obtained. Results: Of 158 patients, 66 (42%) women were included and were followed for a mean of 3.1 years. The women were older (77 ± 7 vs. 74 ± 7 years, p < 0.01) and had lower mortality (24% vs. 43%, p < 0.05) than the men. No gender differences in etiology or medication were found. LV mass index (LVMI 132 ± 42 vs. 156 ± 21 g/m2, p < 0.01) was lower in women. Mortality in women was related to lower LV ejection fraction, larger LV volumes, and higher LVMI (all p < 0.05). In multivariate analysis, LVMI was the strongest independent mortality predictor in women (adjusted hazard ratio [HR] LMVI >125 g/m2 7.4 [1.5-35.5], p = 0.01), whereas this association was not found in men. Conclusions: In patients hospitalized with systolic heart failure, women had lower mortality than men. In women, an increased LVMI was a stronger predictor of mortality than traditional measures of LV size and function. LVMI should be considered for assessment of prognosis in women with heart failure. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Hypothesis: We investigated the hypothesis that there are prognostic differences in the importance of left ventricular (LV) mass and function between male and female patients hospitalized with heart failure. Methods: Patients >=60 years old hospitalized with New York Heart Association class II-IV heart failure and LV systolic dysfunction were prospectively followed for >=18 months. At study start, a physical examination and echocardiography were performed, and blood chemistry samples were obtained. Results: Of 158 patients, 66 (42%) women were included and were followed for a mean of 3.1 years. The women were older (77 ± 7 vs. 74 ± 7 years, p < 0.01) and had lower mortality (24% vs. 43%, p < 0.05) than the men. No gender differences in etiology or medication were found. LV mass index (LVMI 132 ± 42 vs. 156 ± 21 g/m2, p < 0.01) was lower in women. Mortality in women was related to lower LV ejection fraction, larger LV volumes, and higher LVMI (all p < 0.05). In multivariate analysis, LVMI was the strongest independent mortality predictor in women (adjusted hazard ratio [HR] LMVI >125 g/m2 7.4 [1.5-35.5], p = 0.01), whereas this association was not found in men. Conclusions: In patients hospitalized with systolic heart failure, women had lower mortality than men. In women, an increased LVMI was a stronger predictor of mortality than traditional measures of LV size and function. LVMI should be considered for assessment of prognosis in women with heart failure. [ABSTRACT FROM AUTHOR]
ISSN:15409996
DOI:10.1089/jwh.2007.0487