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Sex differences in systolic heart failure in the elderly: the prognostic importance of left ventricular mass in women.

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Title: Sex differences in systolic heart failure in the elderly: the prognostic importance of left ventricular mass in women.
Authors: Mejhert M (AUTHOR), Kahan T (AUTHOR), Edner M (AUTHOR), Persson HE (AUTHOR)
Source: Journal of Women's Health (15409996). Apr2008, Vol. 17 Issue 3, p373-381. 9p.
Subjects: Hypothesis, Sex differences (Biology), Sex (Biology), Cardiac contraction, Prognostic tests, Prognosis, Heart failure
Abstract: Hypothesis: We investigated the hypothesis that there are prognostic differences in the importance of left ventricular (LV) mass and function between male and female patients hospitalized with heart failure. Methods: Patients >=60 years old hospitalized with New York Heart Association class II-IV heart failure and LV systolic dysfunction were prospectively followed for >=18 months. At study start, a physical examination and echocardiography were performed, and blood chemistry samples were obtained. Results: Of 158 patients, 66 (42%) women were included and were followed for a mean of 3.1 years. The women were older (77 ± 7 vs. 74 ± 7 years, p < 0.01) and had lower mortality (24% vs. 43%, p < 0.05) than the men. No gender differences in etiology or medication were found. LV mass index (LVMI 132 ± 42 vs. 156 ± 21 g/m2, p < 0.01) was lower in women. Mortality in women was related to lower LV ejection fraction, larger LV volumes, and higher LVMI (all p < 0.05). In multivariate analysis, LVMI was the strongest independent mortality predictor in women (adjusted hazard ratio [HR] LMVI >125 g/m2 7.4 [1.5-35.5], p = 0.01), whereas this association was not found in men. Conclusions: In patients hospitalized with systolic heart failure, women had lower mortality than men. In women, an increased LVMI was a stronger predictor of mortality than traditional measures of LV size and function. LVMI should be considered for assessment of prognosis in women with heart failure. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Sex differences in systolic heart failure in the elderly: the prognostic importance of left ventricular mass in women.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mejhert+M%22&quot;&gt;Mejhert M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kahan+T%22&quot;&gt;Kahan T&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Edner+M%22&quot;&gt;Edner M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Persson+HE%22&quot;&gt;Persson HE&lt;/searchLink&gt; (AUTHOR)
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Hypothesis: We investigated the hypothesis that there are prognostic differences in the importance of left ventricular (LV) mass and function between male and female patients hospitalized with heart failure. Methods: Patients &gt;=60 years old hospitalized with New York Heart Association class II-IV heart failure and LV systolic dysfunction were prospectively followed for &gt;=18 months. At study start, a physical examination and echocardiography were performed, and blood chemistry samples were obtained. Results: Of 158 patients, 66 (42%) women were included and were followed for a mean of 3.1 years. The women were older (77 &#177; 7 vs. 74 &#177; 7 years, p &lt; 0.01) and had lower mortality (24% vs. 43%, p &lt; 0.05) than the men. No gender differences in etiology or medication were found. LV mass index (LVMI 132 &#177; 42 vs. 156 &#177; 21 g/m2, p &lt; 0.01) was lower in women. Mortality in women was related to lower LV ejection fraction, larger LV volumes, and higher LVMI (all p &lt; 0.05). In multivariate analysis, LVMI was the strongest independent mortality predictor in women (adjusted hazard ratio [HR] LMVI &gt;125 g/m2 7.4 [1.5-35.5], p = 0.01), whereas this association was not found in men. Conclusions: In patients hospitalized with systolic heart failure, women had lower mortality than men. In women, an increased LVMI was a stronger predictor of mortality than traditional measures of LV size and function. LVMI should be considered for assessment of prognosis in women with heart failure. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Journal of Women&#39;s Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105744765
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1089/jwh.2007.0487
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 373
    Subjects:
      – SubjectFull: Hypothesis
        Type: general
      – SubjectFull: Sex differences (Biology)
        Type: general
      – SubjectFull: Sex (Biology)
        Type: general
      – SubjectFull: Cardiac contraction
        Type: general
      – SubjectFull: Prognostic tests
        Type: general
      – SubjectFull: Prognosis
        Type: general
      – SubjectFull: Heart failure
        Type: general
    Titles:
      – TitleFull: Sex differences in systolic heart failure in the elderly: the prognostic importance of left ventricular mass in women.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Mejhert M
      – PersonEntity:
          Name:
            NameFull: Kahan T
      – PersonEntity:
          Name:
            NameFull: Edner M
      – PersonEntity:
          Name:
            NameFull: Persson HE
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      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2008
              Type: published
              Y: 2008
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              Value: 15409996
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              Value: 17
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Journal of Women's Health (15409996)
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