High-concentration nitrous oxide for procedural sedation in children: adverse events and depth of sedation.
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| Title: | High-concentration nitrous oxide for procedural sedation in children: adverse events and depth of sedation. |
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| Authors: | Babl FE (AUTHOR), Oakley E (AUTHOR), Seaman C (AUTHOR), Barnett P (AUTHOR), Sharwood LN (AUTHOR) |
| Source: | Pediatrics. Mar2008, Vol. 121 Issue 3, pe528-32. 1p. |
| Abstract: | OBJECTIVE: Nitrous oxide is an attractive agent for procedural sedation and analgesia in the emergency department; however, there are limited safety data for high-concentration continuous-flow nitrous oxide (50%-70%) and its use in young children. We set out to characterize the depth of sedation and incidence of adverse events associated with various concentrations of nitrous oxide used in a pediatric emergency department. METHODS: This was a prospective observational study of nitrous oxide use for procedural sedation and analgesia in a tertiary children's hospital emergency department. Nitrous oxide concentration, adverse events, and sedation depth were recorded. Adverse events were categorized as mild or serious. Sedation depth was recorded on a sedation scale from 0 to 6. RESULTS: A total of 762 patients who were aged 1 to 17 years received nitrous oxide during the 2-year study period. A total of 548 (72%) received nitrous oxide 70%, and 101 (13%) received nitrous oxide 50%. Moderate or deep sedation with scores of < or = 2 occurred in 3% of patients who had received nitrous oxide 70% and no patients who had received nitrous oxide 50%. Mean sedation scores were 4.4 at nitrous oxide 70% and 4.6 at nitrous oxide 50%. Sixty-three (8.3%) patients sustained 70 mild and self-resolving adverse events, most of which were vomiting (5.7%); 2 (0.2%) patients had serious adverse events. There was no significant difference in adverse events rates between nitrous oxide 70% (8.4%) and nitrous oxide 50% (9.9%). There was no significant difference in the percentage of deep sedation when children who were < or = 3 years of age (2.9%) were compared with older children (2.8%). CONCLUSIONS: In this largest prospective emergency department series, high-concentration continuous-flow nitrous oxide (70%) was found to be a safe agent for procedural sedation and analgesia when embedded in a comprehensive sedation program. Nitrous oxide also seems safe in children aged 1 to 3 years. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105767978 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: High-concentration nitrous oxide for procedural sedation in children: adverse events and depth of sedation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Babl+FE%22">Babl FE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oakley+E%22">Oakley E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seaman+C%22">Seaman C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barnett+P%22">Barnett P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharwood+LN%22">Sharwood LN</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Mar2008, Vol. 121 Issue 3, pe528-32. 1p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVE: Nitrous oxide is an attractive agent for procedural sedation and analgesia in the emergency department; however, there are limited safety data for high-concentration continuous-flow nitrous oxide (50%-70%) and its use in young children. We set out to characterize the depth of sedation and incidence of adverse events associated with various concentrations of nitrous oxide used in a pediatric emergency department. METHODS: This was a prospective observational study of nitrous oxide use for procedural sedation and analgesia in a tertiary children's hospital emergency department. Nitrous oxide concentration, adverse events, and sedation depth were recorded. Adverse events were categorized as mild or serious. Sedation depth was recorded on a sedation scale from 0 to 6. RESULTS: A total of 762 patients who were aged 1 to 17 years received nitrous oxide during the 2-year study period. A total of 548 (72%) received nitrous oxide 70%, and 101 (13%) received nitrous oxide 50%. Moderate or deep sedation with scores of < or = 2 occurred in 3% of patients who had received nitrous oxide 70% and no patients who had received nitrous oxide 50%. Mean sedation scores were 4.4 at nitrous oxide 70% and 4.6 at nitrous oxide 50%. Sixty-three (8.3%) patients sustained 70 mild and self-resolving adverse events, most of which were vomiting (5.7%); 2 (0.2%) patients had serious adverse events. There was no significant difference in adverse events rates between nitrous oxide 70% (8.4%) and nitrous oxide 50% (9.9%). There was no significant difference in the percentage of deep sedation when children who were < or = 3 years of age (2.9%) were compared with older children (2.8%). CONCLUSIONS: In this largest prospective emergency department series, high-concentration continuous-flow nitrous oxide (70%) was found to be a safe agent for procedural sedation and analgesia when embedded in a comprehensive sedation program. Nitrous oxide also seems safe in children aged 1 to 3 years. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2007-1044 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e528 Titles: – TitleFull: High-concentration nitrous oxide for procedural sedation in children: adverse events and depth of sedation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Babl FE – PersonEntity: Name: NameFull: Oakley E – PersonEntity: Name: NameFull: Seaman C – PersonEntity: Name: NameFull: Barnett P – PersonEntity: Name: NameFull: Sharwood LN IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 121 – Type: issue Value: 3 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
