Attention-deficit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system.
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| Title: | Attention-deficit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system. |
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| Authors: | Gau SS (AUTHOR), Chang LY (AUTHOR), Huang LM (AUTHOR), Fan TY (AUTHOR), Wu YY (AUTHOR), Lin TY (AUTHOR) |
| Source: | Pediatrics. Aug2008, Vol. 122 Issue 2, pe452-8. 1p. |
| Abstract: | BACKGROUND: No study has investigated the association between enterovirus 71 central nervous system infection and symptoms related to attention-deficit/hyperactivity disorder. In this study we evaluated attention-deficit/hyperactivity disorder-related symptoms and internalizing problems as long-term sequelae resulting from enterovirus 71 central nervous system infection in children. METHODS: We enrolled 86 children 4 to 16 years old with virus-culture-confirmed enterovirus 71 infection and central nervous system involvement diagnosed 3 to 7 years before the study and 172 control subjects, matched for age, gender, and parents' education levels. Their mothers and teachers were asked to report on possible attention-deficit/hyperactivity disorder-related symptoms, and their mothers were asked to report on possible internalizing problems. All of the children previously infected with enterovirus 71 received intelligence tests. RESULTS: Forty-two (49%) of the children previously infected with enterovirus 71 had had viral meningitis; 35 (41%) had severe central nervous system involvement, such as encephalitis, poliomyelitis-like syndrome, or encephalomyelitis; and 9 (10%) had cardiopulmonary failure and central nervous system involvement. The children previously infected with enterovirus 71 had higher scores than matched control subjects on teacher- and mother-rated scales of inattention, hyperactivity-impulsivity, oppositional symptoms, and attention-deficit/hyperactivity disorder index. The rate of elevated attention-deficit/hyperactivity disorder-related symptoms among children with enterovirus 71 central nervous system infection was 20%, whereas that rate among matched control subjects was only 3%. They also had more internalizing problems. Their verbal and performance IQs, as well as verbal comprehension indices, were significantly inversely correlated with symptoms of inattention, hyperactivity-impulsivity, and attention-deficit/hyperactivity disorder index scores. CONCLUSIONS: Enterovirus 71 central nervous system infection may affect long-term regulation of attention and emotion and cause hyperactivity-impulsivity in children. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105809047 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Attention-deficit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gau+SS%22">Gau SS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang+LY%22">Chang LY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang+LM%22">Huang LM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan+TY%22">Fan TY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu+YY%22">Wu YY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin+TY%22">Lin TY</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Aug2008, Vol. 122 Issue 2, pe452-8. 1p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: No study has investigated the association between enterovirus 71 central nervous system infection and symptoms related to attention-deficit/hyperactivity disorder. In this study we evaluated attention-deficit/hyperactivity disorder-related symptoms and internalizing problems as long-term sequelae resulting from enterovirus 71 central nervous system infection in children. METHODS: We enrolled 86 children 4 to 16 years old with virus-culture-confirmed enterovirus 71 infection and central nervous system involvement diagnosed 3 to 7 years before the study and 172 control subjects, matched for age, gender, and parents' education levels. Their mothers and teachers were asked to report on possible attention-deficit/hyperactivity disorder-related symptoms, and their mothers were asked to report on possible internalizing problems. All of the children previously infected with enterovirus 71 received intelligence tests. RESULTS: Forty-two (49%) of the children previously infected with enterovirus 71 had had viral meningitis; 35 (41%) had severe central nervous system involvement, such as encephalitis, poliomyelitis-like syndrome, or encephalomyelitis; and 9 (10%) had cardiopulmonary failure and central nervous system involvement. The children previously infected with enterovirus 71 had higher scores than matched control subjects on teacher- and mother-rated scales of inattention, hyperactivity-impulsivity, oppositional symptoms, and attention-deficit/hyperactivity disorder index. The rate of elevated attention-deficit/hyperactivity disorder-related symptoms among children with enterovirus 71 central nervous system infection was 20%, whereas that rate among matched control subjects was only 3%. They also had more internalizing problems. Their verbal and performance IQs, as well as verbal comprehension indices, were significantly inversely correlated with symptoms of inattention, hyperactivity-impulsivity, and attention-deficit/hyperactivity disorder index scores. CONCLUSIONS: Enterovirus 71 central nervous system infection may affect long-term regulation of attention and emotion and cause hyperactivity-impulsivity in children. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2007-3799 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e452 Titles: – TitleFull: Attention-deficit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gau SS – PersonEntity: Name: NameFull: Chang LY – PersonEntity: Name: NameFull: Huang LM – PersonEntity: Name: NameFull: Fan TY – PersonEntity: Name: NameFull: Wu YY – PersonEntity: Name: NameFull: Lin TY IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 122 – Type: issue Value: 2 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
