Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats.
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| Title: | Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats. |
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| Authors: | Huang KL (AUTHOR), Chen CS (AUTHOR), Hsu CW (AUTHOR), Li MH (AUTHOR), Chang H (AUTHOR), Tsai SH (AUTHOR), Chu SJ (AUTHOR) |
| Source: | American Journal of Chinese Medicine. 2008, Vol. 36 Issue 2, p301-311. 11p. |
| Abstract: | Baicalin is a flavonoid present in many traditional Chinese medicines. A number of studies show that baicalin has anti-inflammatory actions and protects against a variety of tissue and organ injuries. The effect of baicalin in lipopolysaccharide (LPS)-induced acute lung injury is not well studied. In this study, typically acute lung injury was induced in rat by intratracheal injection of LPS, which increased lactate dehydrogenase activity and protein content in bronchoalveolar lavage fluid, wet/dry lung weight ratio, Evan's blue dye leakage, and neutrophil infiltration. Baicalin (20 mg/kg) was administrated 1 hour before or 30 min after LPS injection. Both pre and post-treatment with baicalin attenuated the increase of these parameters and improved histological finding. Our results suggest that baicalin has a therapeutic effect on LPS-induced acute lung injury. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105815697 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Huang+KL%22">Huang KL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen+CS%22">Chen CS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hsu+CW%22">Hsu CW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li+MH%22">Li MH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang+H%22">Chang H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsai+SH%22">Tsai SH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chu+SJ%22">Chu SJ</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2008, Vol. 36 Issue 2, p301-311. 11p. – Name: Abstract Label: Abstract Group: Ab Data: Baicalin is a flavonoid present in many traditional Chinese medicines. A number of studies show that baicalin has anti-inflammatory actions and protects against a variety of tissue and organ injuries. The effect of baicalin in lipopolysaccharide (LPS)-induced acute lung injury is not well studied. In this study, typically acute lung injury was induced in rat by intratracheal injection of LPS, which increased lactate dehydrogenase activity and protein content in bronchoalveolar lavage fluid, wet/dry lung weight ratio, Evan's blue dye leakage, and neutrophil infiltration. Baicalin (20 mg/kg) was administrated 1 hour before or 30 min after LPS injection. Both pre and post-treatment with baicalin attenuated the increase of these parameters and improved histological finding. Our results suggest that baicalin has a therapeutic effect on LPS-induced acute lung injury. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105815697 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1142/s0192415x08005783 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 301 Titles: – TitleFull: Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Huang KL – PersonEntity: Name: NameFull: Chen CS – PersonEntity: Name: NameFull: Hsu CW – PersonEntity: Name: NameFull: Li MH – PersonEntity: Name: NameFull: Chang H – PersonEntity: Name: NameFull: Tsai SH – PersonEntity: Name: NameFull: Chu SJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 0192415X Numbering: – Type: volume Value: 36 – Type: issue Value: 2 Titles: – TitleFull: American Journal of Chinese Medicine Type: main |
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