Menopause transition stage and endogenous estradiol and follicle-stimulating hormone levels are not related to cognitive performance: cross-sectional results from the study of women's health across the nation (swan)
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| Title: | Menopause transition stage and endogenous estradiol and follicle-stimulating hormone levels are not related to cognitive performance: cross-sectional results from the study of women's health across the nation (swan) |
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| Authors: | Luetters C (AUTHOR), Huang M (AUTHOR), Seeman T (AUTHOR), Buckwalter G (AUTHOR), Meyer PM (AUTHOR), Avis NE (AUTHOR), Sternfeld B (AUTHOR), Johnston JM (AUTHOR), Greendale GA (AUTHOR) |
| Source: | Journal of Women's Health (15409996). Apr2007, Vol. 16 Issue 3, p331-344. 14p. |
| Subjects: | Menopause, Estradiol, Follicle-stimulating hormone, Perimenopause, Climacteric, Estrogen, Glycoprotein hormones, Physiology of women, Women's health |
| Abstract: | Background: By one estimate, 60% of women experiencing the menopause transition perceive that they have memory problems, but most studies that have used cognitive function tests have not substantiated a relation between menopause stage and cognitive performance. We sought to describe the cross-sectional relation between menopause status, estradiol (E2), follicle-stimulating hormone (FSH), and measured cognitive function. Methods: Cross sectional analysis of a community-based cohort of midlife women was used. Cognitive tests were the East Boston Memory Test, Symbol Digit Modalities, and Digits Span Backward. Menopause categories (premenopausal, early perimenopausal, late perimenopausal, and postmenopausal) were defined based on menstrual patterns. One set of general linear models assessed the relations between each cognitive test and menopause transition category, initially adjusted for age, race/ethnicity, education, symptoms, self-rated general health, and body mass index (BMI); next, these were additionally adjusted for FSH and E2. A second set of models, stratified by menopause status, examined the possible relations between each cognitive test and either E2 or FSH, adjusted for age, race/ethnicity, education, symptoms, self-related general health, and BMI. Results: The mean age of the analytical sample ( n = 1657) was 49.7 years. Only 5% of the sample had less than a high school education, 16% graduated from high school, and the rest had at least some college. The percent of women in each menopause category was premenopausal (9.0%), early perimenopausal (57.0%), late perimenopausal (13.4%), postmenopausal (20.6%). Although clinical-site adjusted models showed moderate differences between menopause transition groups and cognitive performance, no association was found between each of the measured cognitive performance tests and menopause transition status when adjusting for covariates. Similarly, no association between each cognitive test and E2 or FSH was found. Conclusions: This study does not support a cross-sectional relation between cognitive test performance and menopause stage, FSH, or E2. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105834709 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Menopause transition stage and endogenous estradiol and follicle-stimulating hormone levels are not related to cognitive performance: cross-sectional results from the study of women's health across the nation (swan) – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Luetters+C%22">Luetters C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang+M%22">Huang M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seeman+T%22">Seeman T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buckwalter+G%22">Buckwalter G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meyer+PM%22">Meyer PM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Avis+NE%22">Avis NE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sternfeld+B%22">Sternfeld B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Johnston+JM%22">Johnston JM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greendale+GA%22">Greendale GA</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Women's+Health+%2815409996%29%22">Journal of Women's Health (15409996)</searchLink>. Apr2007, Vol. 16 Issue 3, p331-344. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Menopause%22">Menopause</searchLink><br /><searchLink fieldCode="DE" term="%22Estradiol%22">Estradiol</searchLink><br /><searchLink fieldCode="DE" term="%22Follicle-stimulating+hormone%22">Follicle-stimulating hormone</searchLink><br /><searchLink fieldCode="DE" term="%22Perimenopause%22">Perimenopause</searchLink><br /><searchLink fieldCode="DE" term="%22Climacteric%22">Climacteric</searchLink><br /><searchLink fieldCode="DE" term="%22Estrogen%22">Estrogen</searchLink><br /><searchLink fieldCode="DE" term="%22Glycoprotein+hormones%22">Glycoprotein hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology+of+women%22">Physiology of women</searchLink><br /><searchLink fieldCode="DE" term="%22Women's+health%22">Women's health</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: By one estimate, 60% of women experiencing the menopause transition perceive that they have memory problems, but most studies that have used cognitive function tests have not substantiated a relation between menopause stage and cognitive performance. We sought to describe the cross-sectional relation between menopause status, estradiol (E2), follicle-stimulating hormone (FSH), and measured cognitive function. Methods: Cross sectional analysis of a community-based cohort of midlife women was used. Cognitive tests were the East Boston Memory Test, Symbol Digit Modalities, and Digits Span Backward. Menopause categories (premenopausal, early perimenopausal, late perimenopausal, and postmenopausal) were defined based on menstrual patterns. One set of general linear models assessed the relations between each cognitive test and menopause transition category, initially adjusted for age, race/ethnicity, education, symptoms, self-rated general health, and body mass index (BMI); next, these were additionally adjusted for FSH and E2. A second set of models, stratified by menopause status, examined the possible relations between each cognitive test and either E2 or FSH, adjusted for age, race/ethnicity, education, symptoms, self-related general health, and BMI. Results: The mean age of the analytical sample ( n = 1657) was 49.7 years. Only 5% of the sample had less than a high school education, 16% graduated from high school, and the rest had at least some college. The percent of women in each menopause category was premenopausal (9.0%), early perimenopausal (57.0%), late perimenopausal (13.4%), postmenopausal (20.6%). Although clinical-site adjusted models showed moderate differences between menopause transition groups and cognitive performance, no association was found between each of the measured cognitive performance tests and menopause transition status when adjusting for covariates. Similarly, no association between each cognitive test and E2 or FSH was found. Conclusions: This study does not support a cross-sectional relation between cognitive test performance and menopause stage, FSH, or E2. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1089/jwh.2006.0057 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 331 Subjects: – SubjectFull: Menopause Type: general – SubjectFull: Estradiol Type: general – SubjectFull: Follicle-stimulating hormone Type: general – SubjectFull: Perimenopause Type: general – SubjectFull: Climacteric Type: general – SubjectFull: Estrogen Type: general – SubjectFull: Glycoprotein hormones Type: general – SubjectFull: Physiology of women Type: general – SubjectFull: Women's health Type: general Titles: – TitleFull: Menopause transition stage and endogenous estradiol and follicle-stimulating hormone levels are not related to cognitive performance: cross-sectional results from the study of women's health across the nation (swan) Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Luetters C – PersonEntity: Name: NameFull: Huang M – PersonEntity: Name: NameFull: Seeman T – PersonEntity: Name: NameFull: Buckwalter G – PersonEntity: Name: NameFull: Meyer PM – PersonEntity: Name: NameFull: Avis NE – PersonEntity: Name: NameFull: Sternfeld B – PersonEntity: Name: NameFull: Johnston JM – PersonEntity: Name: NameFull: Greendale GA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 15409996 Numbering: – Type: volume Value: 16 – Type: issue Value: 3 Titles: – TitleFull: Journal of Women's Health (15409996) Type: main |
| ResultId | 1 |
