Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation.
Saved in:
| Title: | Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation. |
|---|---|
| Authors: | Sachdev PS (AUTHOR), Loo CK (AUTHOR), Mitchell PB (AUTHOR), McFarquhar TF (AUTHOR), Malhi GS (AUTHOR) |
| Source: | Psychological Medicine. Nov2007, Vol. 37 Issue 11, p1645-1649. 5p. |
| Abstract: | ABSTRACT BACKGROUND: To determine the efficacy and tolerability of repetitive transcranial magnetic stimulation (rTMS) as a treatment for obsessive compulsive disorder (OCD) in a double-blind placebo-controlled study.MethodSubjects with treatment-resistant OCD were randomized to rTMS (n=10) or sham rTMS (n=8) for 10 sessions of daily stimulation over the left dorsolateral prefrontal cortex (DLPFC), with subjects and raters being blind to the treatment. Subjects were offered an open extension of up to 20 sessions of rTMS. RESULTS: The two groups did not differ on change in Yale-Brown Obsessive Compulsive Scale (YBOCS) or Maudsley Obsessive-Compulsive Inventory scores over 10 sessions, with or without correction for depression ratings. Over 20 sessions, there was a significant reduction in total YBOCS scores, but not after controlling for depression. rTMS over 20 sessions was well tolerated.ConclusionTwo weeks of rTMS over the left DLPFC is ineffective for treatment-resistant OCD. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105835860 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sachdev+PS%22">Sachdev PS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Loo+CK%22">Loo CK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mitchell+PB%22">Mitchell PB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McFarquhar+TF%22">McFarquhar TF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Malhi+GS%22">Malhi GS</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Nov2007, Vol. 37 Issue 11, p1645-1649. 5p. – Name: Abstract Label: Abstract Group: Ab Data: ABSTRACT BACKGROUND: To determine the efficacy and tolerability of repetitive transcranial magnetic stimulation (rTMS) as a treatment for obsessive compulsive disorder (OCD) in a double-blind placebo-controlled study.MethodSubjects with treatment-resistant OCD were randomized to rTMS (n=10) or sham rTMS (n=8) for 10 sessions of daily stimulation over the left dorsolateral prefrontal cortex (DLPFC), with subjects and raters being blind to the treatment. Subjects were offered an open extension of up to 20 sessions of rTMS. RESULTS: The two groups did not differ on change in Yale-Brown Obsessive Compulsive Scale (YBOCS) or Maudsley Obsessive-Compulsive Inventory scores over 10 sessions, with or without correction for depression ratings. Over 20 sessions, there was a significant reduction in total YBOCS scores, but not after controlling for depression. rTMS over 20 sessions was well tolerated.ConclusionTwo weeks of rTMS over the left DLPFC is ineffective for treatment-resistant OCD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105835860 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/s0033291707001092 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1645 Titles: – TitleFull: Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sachdev PS – PersonEntity: Name: NameFull: Loo CK – PersonEntity: Name: NameFull: Mitchell PB – PersonEntity: Name: NameFull: McFarquhar TF – PersonEntity: Name: NameFull: Malhi GS IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 00332917 Numbering: – Type: volume Value: 37 – Type: issue Value: 11 Titles: – TitleFull: Psychological Medicine Type: main |
| ResultId | 1 |
