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Lack of autoantibody expression in children born to mothers with silicone breast implants.

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Title: Lack of autoantibody expression in children born to mothers with silicone breast implants.
Authors: Levine JJ (AUTHOR), Lin HC (AUTHOR), Rowley M (AUTHOR), Cook A (AUTHOR), Teuber SS (AUTHOR), Ilowite NT (AUTHOR)
Source: Pediatrics. Feb96, Vol. 97 Issue 2, p243-245. 3p.
Abstract: OBJECTIVE: We determined systematically the prevalence of autoantibodies in children born to mothers with silicone breast implants and the relationships with clinical symptoms and methods of exposure. METHODS: Autoantibody expression was determined in 80 children born to mothers with silicone implants and in 42 controls. A clinical assessment score was assigned to each patient. Antinuclear antibodies as well as antibodies to mitochondrial, smooth muscle, striational, myocardial, parietal cell, reticulin tissues, or subcellular compartments were measured by indirect fluorescent assay. Antibodies to nRNP (U1-RNP/snRNP); Sm; SS-A; SS-B; Scl-70; thyroid microsome; immunoglobulin (Ig)G, IgM, and IgA antibodies to cardiolipin; and antibodies to native and denatured human types I and II collagen were measured by enzyme-linked immunosorbent assay. Serum complement components C3 and C4 and IgM rheumatoid factor were measured by nephelometry. RESULTS: Autoantibody prevalence was not significantly different between children born to mothers with silicone implants and controls. The presence of autoantibodies was not related to the children's clinical symptoms or to the method of exposure. CONCLUSIONS: Determination of autoantibody production is of limited clinical utility in the evaluation of children born to mothers with silicone breast implants. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Lack of autoantibody expression in children born to mothers with silicone breast implants.
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  Data: <searchLink fieldCode="AR" term="%22Levine+JJ%22">Levine JJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin+HC%22">Lin HC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rowley+M%22">Rowley M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cook+A%22">Cook A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Teuber+SS%22">Teuber SS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ilowite+NT%22">Ilowite NT</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Feb96, Vol. 97 Issue 2, p243-245. 3p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: OBJECTIVE: We determined systematically the prevalence of autoantibodies in children born to mothers with silicone breast implants and the relationships with clinical symptoms and methods of exposure. METHODS: Autoantibody expression was determined in 80 children born to mothers with silicone implants and in 42 controls. A clinical assessment score was assigned to each patient. Antinuclear antibodies as well as antibodies to mitochondrial, smooth muscle, striational, myocardial, parietal cell, reticulin tissues, or subcellular compartments were measured by indirect fluorescent assay. Antibodies to nRNP (U1-RNP/snRNP); Sm; SS-A; SS-B; Scl-70; thyroid microsome; immunoglobulin (Ig)G, IgM, and IgA antibodies to cardiolipin; and antibodies to native and denatured human types I and II collagen were measured by enzyme-linked immunosorbent assay. Serum complement components C3 and C4 and IgM rheumatoid factor were measured by nephelometry. RESULTS: Autoantibody prevalence was not significantly different between children born to mothers with silicone implants and controls. The presence of autoantibodies was not related to the children's clinical symptoms or to the method of exposure. CONCLUSIONS: Determination of autoantibody production is of limited clinical utility in the evaluation of children born to mothers with silicone breast implants. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1542/peds.97.2.243
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      – Code: eng
        Text: English
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      – TitleFull: Lack of autoantibody expression in children born to mothers with silicone breast implants.
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            NameFull: Levine JJ
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            NameFull: Lin HC
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              Text: Feb96
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              Y: 1996
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