The treatment of attention-deficit hyperactivity disorder in Tourette's syndrome: a double-blind placebo-controlled study with clonidine and desipramine.
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| Title: | The treatment of attention-deficit hyperactivity disorder in Tourette's syndrome: a double-blind placebo-controlled study with clonidine and desipramine. |
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| Authors: | Singer HS (AUTHOR), Brown J (AUTHOR), Quaskey S (AUTHOR), Rosenberg LA (AUTHOR), Mellits ED (AUTHOR), Denckla MB (AUTHOR) |
| Source: | Pediatrics. Jan95, Vol. 95 Issue 1, p74-81. 8p. |
| Abstract: | OBJECTIVES. Because psychostimulants can exacerbate preexisting motor/phonic tics in individuals with Tourette's syndrome (TS), a clinical trial was performed to examine the ability of clonidine and desipramine to modify attention-deficit hyperactivity disorder (ADHD) behaviors in children with TS + ADHD. METHODS. A double-blind, placebo-controlled protocol was used in which each subject served as his or her own control and received, in a randomly assigned fashion, 6-week medication cycles with clonidine (0.05 mg four times daily), desipramine (25 mg four times daily), and placebo. RESULTS. Thirty-seven children with TS+ADHD between the ages 7 to 13 years and of normal intellect were recruited, and 34 (31 males, 3 females) completed the entire protocol. Outcome measures for ADHD included Parent and Teacher Child Behavior Checklists (CBCL), continuous performance tests, and neuropsychologic tests of executive function. Several markers for ADHD were shown to improve significantly (P < .05) after treatment with desipramine (parent linear analogue rating, parent CBCL 'hyperactivity' subscale, and teacher CBCL subscales 'nervous/overactive,' 'anxious,' and 'unpopular'). Improvement with desipramine was always superior to that noted with clonidine. Clinical improvement did not correlate with drug blood levels. On measures of tic severity, neither drug made tics worse. Desipramine showed a statistically significant improvement on a global linear analogue scale, but not on the Hopkins Motor/Vocal Tic Severity Scale, the Tourette Syndrome Severity Scale, or the Yale Global Tic Severity Scale. Clonidine did not significantly alter tic severity on any measure. CONCLUSION. The results of this study suggest that desipramine may be a useful alternative for the treatment of symptoms of ADHD in children with TS. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105976675 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The treatment of attention-deficit hyperactivity disorder in Tourette's syndrome: a double-blind placebo-controlled study with clonidine and desipramine. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Singer+HS%22">Singer HS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brown+J%22">Brown J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quaskey+S%22">Quaskey S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rosenberg+LA%22">Rosenberg LA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mellits+ED%22">Mellits ED</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Denckla+MB%22">Denckla MB</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Jan95, Vol. 95 Issue 1, p74-81. 8p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVES. Because psychostimulants can exacerbate preexisting motor/phonic tics in individuals with Tourette's syndrome (TS), a clinical trial was performed to examine the ability of clonidine and desipramine to modify attention-deficit hyperactivity disorder (ADHD) behaviors in children with TS + ADHD. METHODS. A double-blind, placebo-controlled protocol was used in which each subject served as his or her own control and received, in a randomly assigned fashion, 6-week medication cycles with clonidine (0.05 mg four times daily), desipramine (25 mg four times daily), and placebo. RESULTS. Thirty-seven children with TS+ADHD between the ages 7 to 13 years and of normal intellect were recruited, and 34 (31 males, 3 females) completed the entire protocol. Outcome measures for ADHD included Parent and Teacher Child Behavior Checklists (CBCL), continuous performance tests, and neuropsychologic tests of executive function. Several markers for ADHD were shown to improve significantly (P < .05) after treatment with desipramine (parent linear analogue rating, parent CBCL 'hyperactivity' subscale, and teacher CBCL subscales 'nervous/overactive,' 'anxious,' and 'unpopular'). Improvement with desipramine was always superior to that noted with clonidine. Clinical improvement did not correlate with drug blood levels. On measures of tic severity, neither drug made tics worse. Desipramine showed a statistically significant improvement on a global linear analogue scale, but not on the Hopkins Motor/Vocal Tic Severity Scale, the Tourette Syndrome Severity Scale, or the Yale Global Tic Severity Scale. Clonidine did not significantly alter tic severity on any measure. CONCLUSION. The results of this study suggest that desipramine may be a useful alternative for the treatment of symptoms of ADHD in children with TS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105976675 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.95.1.74 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 74 Titles: – TitleFull: The treatment of attention-deficit hyperactivity disorder in Tourette's syndrome: a double-blind placebo-controlled study with clonidine and desipramine. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Singer HS – PersonEntity: Name: NameFull: Brown J – PersonEntity: Name: NameFull: Quaskey S – PersonEntity: Name: NameFull: Rosenberg LA – PersonEntity: Name: NameFull: Mellits ED – PersonEntity: Name: NameFull: Denckla MB IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan95 Type: published Y: 1995 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 95 – Type: issue Value: 1 Titles: – TitleFull: Pediatrics Type: main |
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