Localization and expression of MUC5B and MUC7 mucins in pediatric sinus mucosa.
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| Title: | Localization and expression of MUC5B and MUC7 mucins in pediatric sinus mucosa. |
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| Authors: | Peñia MT (AUTHOR), Aujla PK (AUTHOR), Zudaire E (AUTHOR), Watson AM (AUTHOR), Przygodzki R (AUTHOR), Zalzal GH (AUTHOR), Rose MC (AUTHOR) |
| Source: | Annals of Otology, Rhinology & Laryngology. May2007, Vol. 116 Issue 5, p389-397. 9p. |
| Abstract: | OBJECTIVES: The purpose of this study was to analyze the secretory cell population and distribution of MUC5B and MUC7 mucins in the sinus mucosa of pediatric patients with and without chronic rhinosinusitis (CRS). METHODS: Sinus mucosal specimens were collected at surgery in a pediatric tertiary care facility. Histologic, immunohistochemical, and morphometric analyses were performed on sinus mucosa of 20 children with CRS and 7 children without CRS. RESULTS: A significant increase in the area of submucosal glands was evident in the sinus mucosa of children with CRS as compared to controls. MUC5B and MUC7 mucins were expressed in the submucosal glands, as well as in goblet cells, in the sinus mucosa of both populations. No differences in MUC5B or MUC7 expression were observed when mucin expression was normalized to glandular area. CONCLUSIONS: Children with CRS have an increased number of submucosal glands, indicating that glandular mucins contribute to mucus overproduction in CRS. MUC5B and MUC7 mucins, which have previously been considered only glandular mucins, are also expressed in goblet cells in the sinus mucosa. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105984696 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Localization and expression of MUC5B and MUC7 mucins in pediatric sinus mucosa. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Peñia+MT%22">Peñia MT</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aujla+PK%22">Aujla PK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zudaire+E%22">Zudaire E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Watson+AM%22">Watson AM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Przygodzki+R%22">Przygodzki R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zalzal+GH%22">Zalzal GH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rose+MC%22">Rose MC</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22">Annals of Otology, Rhinology & Laryngology</searchLink>. May2007, Vol. 116 Issue 5, p389-397. 9p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVES: The purpose of this study was to analyze the secretory cell population and distribution of MUC5B and MUC7 mucins in the sinus mucosa of pediatric patients with and without chronic rhinosinusitis (CRS). METHODS: Sinus mucosal specimens were collected at surgery in a pediatric tertiary care facility. Histologic, immunohistochemical, and morphometric analyses were performed on sinus mucosa of 20 children with CRS and 7 children without CRS. RESULTS: A significant increase in the area of submucosal glands was evident in the sinus mucosa of children with CRS as compared to controls. MUC5B and MUC7 mucins were expressed in the submucosal glands, as well as in goblet cells, in the sinus mucosa of both populations. No differences in MUC5B or MUC7 expression were observed when mucin expression was normalized to glandular area. CONCLUSIONS: Children with CRS have an increased number of submucosal glands, indicating that glandular mucins contribute to mucus overproduction in CRS. MUC5B and MUC7 mucins, which have previously been considered only glandular mucins, are also expressed in goblet cells in the sinus mucosa. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 389 Titles: – TitleFull: Localization and expression of MUC5B and MUC7 mucins in pediatric sinus mucosa. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Peñia MT – PersonEntity: Name: NameFull: Aujla PK – PersonEntity: Name: NameFull: Zudaire E – PersonEntity: Name: NameFull: Watson AM – PersonEntity: Name: NameFull: Przygodzki R – PersonEntity: Name: NameFull: Zalzal GH – PersonEntity: Name: NameFull: Rose MC IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 00034894 Numbering: – Type: volume Value: 116 – Type: issue Value: 5 Titles: – TitleFull: Annals of Otology, Rhinology & Laryngology Type: main |
| ResultId | 1 |
