Effect of Bauhinia racemosa stem bark on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
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| Title: | Effect of Bauhinia racemosa stem bark on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. |
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| Authors: | Kumar RS (AUTHOR), Sunderam RS (AUTHOR), Sivakumar T (AUTHOR), Sivakumar P (AUTHOR), Sureshkumar R (AUTHOR), Kanagasabi R (AUTHOR), Vijaya M (AUTHOR), Perumal BP (AUTHOR), Gupta M (AUTHOR), Mazumdar UK (AUTHOR), Kumar MS (AUTHOR), Kumar KA (AUTHOR) |
| Source: | American Journal of Chinese Medicine. 2007, Vol. 35 Issue 1, p103-114. 12p. |
| Abstract: | The aim of this study is to investigate the antioxidant defense system induced by the methanol extract of Bauhinia racemosa L.(MEBR) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in Wister albino rats. The effects of MEBR on surface visible macroscopic (Morphometry) liver lesions (neoplastic nodules) and the levels of serum enzymes, lipid peroxidation and antioxidants were evaluated in NDEA-induced hepatocarcinogenesis in rats. In rats treated, with NDEA, significantly elevated levels of serum enzymes (SGOT, SGPT and ALP), bilirubin and decreased levels of protein and uric acid were observed. Significantly elevated amount of malondialdehyde (MDA), the end product of lipidperoxidation, indicated higher levels of lipid peroxidation, which was accompanied by significantly decreased levels of antioxidants like vitamin C, vitamin E, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). Administration of MEBR was able to suppress nodule development/hepatocellular lesion formation in rats. The extract treatment increases in antioxidant levels and dramatic decreases in lipid peroxidation levels. MEBR also produced a protective effect by decreasing the level of serum enzymes, bilirubin and increased the protein and uric acid levels. The results suggest that MEBR exert chemopreventive effects by suppressing nodule development and decreasing lipid peroxidation and enhancing the levels of antioxidants in NDEA carcinogenesis by reducing the formation of free radicals. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106160644 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of Bauhinia racemosa stem bark on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kumar+RS%22">Kumar RS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sunderam+RS%22">Sunderam RS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sivakumar+T%22">Sivakumar T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sivakumar+P%22">Sivakumar P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sureshkumar+R%22">Sureshkumar R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kanagasabi+R%22">Kanagasabi R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vijaya+M%22">Vijaya M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Perumal+BP%22">Perumal BP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta+M%22">Gupta M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mazumdar+UK%22">Mazumdar UK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumar+MS%22">Kumar MS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumar+KA%22">Kumar KA</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2007, Vol. 35 Issue 1, p103-114. 12p. – Name: Abstract Label: Abstract Group: Ab Data: The aim of this study is to investigate the antioxidant defense system induced by the methanol extract of Bauhinia racemosa L.(MEBR) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in Wister albino rats. The effects of MEBR on surface visible macroscopic (Morphometry) liver lesions (neoplastic nodules) and the levels of serum enzymes, lipid peroxidation and antioxidants were evaluated in NDEA-induced hepatocarcinogenesis in rats. In rats treated, with NDEA, significantly elevated levels of serum enzymes (SGOT, SGPT and ALP), bilirubin and decreased levels of protein and uric acid were observed. Significantly elevated amount of malondialdehyde (MDA), the end product of lipidperoxidation, indicated higher levels of lipid peroxidation, which was accompanied by significantly decreased levels of antioxidants like vitamin C, vitamin E, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). Administration of MEBR was able to suppress nodule development/hepatocellular lesion formation in rats. The extract treatment increases in antioxidant levels and dramatic decreases in lipid peroxidation levels. MEBR also produced a protective effect by decreasing the level of serum enzymes, bilirubin and increased the protein and uric acid levels. The results suggest that MEBR exert chemopreventive effects by suppressing nodule development and decreasing lipid peroxidation and enhancing the levels of antioxidants in NDEA carcinogenesis by reducing the formation of free radicals. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1142/s0192415x07004667 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 103 Titles: – TitleFull: Effect of Bauhinia racemosa stem bark on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kumar RS – PersonEntity: Name: NameFull: Sunderam RS – PersonEntity: Name: NameFull: Sivakumar T – PersonEntity: Name: NameFull: Sivakumar P – PersonEntity: Name: NameFull: Sureshkumar R – PersonEntity: Name: NameFull: Kanagasabi R – PersonEntity: Name: NameFull: Vijaya M – PersonEntity: Name: NameFull: Perumal BP – PersonEntity: Name: NameFull: Gupta M – PersonEntity: Name: NameFull: Mazumdar UK – PersonEntity: Name: NameFull: Kumar MS – PersonEntity: Name: NameFull: Kumar KA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 0192415X Numbering: – Type: volume Value: 35 – Type: issue Value: 1 Titles: – TitleFull: American Journal of Chinese Medicine Type: main |
| ResultId | 1 |
