Antioxidant and hepatoprotective effects of Orthosiphon stamineus Benth. standardized extract.
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| Title: | Antioxidant and hepatoprotective effects of Orthosiphon stamineus Benth. standardized extract. |
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| Authors: | Yam MF (AUTHOR), Basir R (AUTHOR), Asmawi MZ (AUTHOR), Ismail Z (AUTHOR) |
| Source: | American Journal of Chinese Medicine. 2007, Vol. 35 Issue 1, p115-126. 12p. |
| Abstract: | Orthosiphon stamineus (OS), Benth. (Lamiaceae) is widely used in Malaysia for treatments of various kidney and liver ailments. In the experiment, DPPH* radicals scavenging, Fe(3+)-induced lipid peroxidation inhibiting activities and trolox equivalent antioxidant capacity (TEAC) of methanol/water extract of Orthosiphon stamineus (SEOS) were determined. The results indicated that SEOS exhibited antioxidant, lipid peroxidation inhibition and free radical scavenging activities. The hepatoprotective activity of the SEOS was studied using CCl(4)-induced liver toxicity in rats. The activity was assessed by monitoring liver function tests through the measurement of alanine transaminase (ALT) and aspartate transaminase (AST). Furthermore, hepatic tissues were also subjected to histopathological studies. Pretreatment of SEOS (125, 250, 500 and 1000 mg/kg p.o.) dose-dependently reduced the necrotic changes in rat liver and inhibited the increase of serum ALT and AST activities. The results of the present study indicated that the hepatoprotective effect of Orthosiphon stamineus might be ascribable to its antioxidant and free radical scavenging property. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106160645 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Antioxidant and hepatoprotective effects of Orthosiphon stamineus Benth. standardized extract. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yam+MF%22">Yam MF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Basir+R%22">Basir R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asmawi+MZ%22">Asmawi MZ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ismail+Z%22">Ismail Z</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2007, Vol. 35 Issue 1, p115-126. 12p. – Name: Abstract Label: Abstract Group: Ab Data: Orthosiphon stamineus (OS), Benth. (Lamiaceae) is widely used in Malaysia for treatments of various kidney and liver ailments. In the experiment, DPPH* radicals scavenging, Fe(3+)-induced lipid peroxidation inhibiting activities and trolox equivalent antioxidant capacity (TEAC) of methanol/water extract of Orthosiphon stamineus (SEOS) were determined. The results indicated that SEOS exhibited antioxidant, lipid peroxidation inhibition and free radical scavenging activities. The hepatoprotective activity of the SEOS was studied using CCl(4)-induced liver toxicity in rats. The activity was assessed by monitoring liver function tests through the measurement of alanine transaminase (ALT) and aspartate transaminase (AST). Furthermore, hepatic tissues were also subjected to histopathological studies. Pretreatment of SEOS (125, 250, 500 and 1000 mg/kg p.o.) dose-dependently reduced the necrotic changes in rat liver and inhibited the increase of serum ALT and AST activities. The results of the present study indicated that the hepatoprotective effect of Orthosiphon stamineus might be ascribable to its antioxidant and free radical scavenging property. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1142/s0192415x07004679 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 115 Titles: – TitleFull: Antioxidant and hepatoprotective effects of Orthosiphon stamineus Benth. standardized extract. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yam MF – PersonEntity: Name: NameFull: Basir R – PersonEntity: Name: NameFull: Asmawi MZ – PersonEntity: Name: NameFull: Ismail Z IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 0192415X Numbering: – Type: volume Value: 35 – Type: issue Value: 1 Titles: – TitleFull: American Journal of Chinese Medicine Type: main |
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