A randomized, controlled trial of heparin versus placebo infusion to prolong the usability of peripherally placed percutaneous central venous catheters (PCVCs) in neonates: the HIP (Heparin Infusion for PCVC) Study.
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| Title: | A randomized, controlled trial of heparin versus placebo infusion to prolong the usability of peripherally placed percutaneous central venous catheters (PCVCs) in neonates: the HIP (Heparin Infusion for PCVC) Study. |
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| Authors: | Shah PS (AUTHOR), Kalyn A (AUTHOR), Satodia P (AUTHOR), Dunn MS (AUTHOR), Parvez B (AUTHOR), Daneman A (AUTHOR), Salem S (AUTHOR), Glanc P (AUTHOR), Ohlsson A (AUTHOR), Shah V (AUTHOR) |
| Source: | Pediatrics. Jan2007, Vol. 119 Issue 1, pe284-91. 1p. |
| Abstract: | BACKGROUND: Mechanical and infectious complications shorten the effective duration of peripherally inserted central venous catheters. Heparin use to prevent such complications and prolong the usability of peripherally inserted central venous catheters is inconclusive. OBJECTIVE: Our goal was to evaluate the effectiveness of heparin in prolonging the usability of peripherally inserted central venous catheters in neonates. DESIGN/METHODS: We performed a multicenter, randomized, controlled trial of heparin infusion (0.5 U/kg per hour) versus placebo for peripherally inserted central venous catheters in neonates. The primary outcome was duration of catheter use. Secondary outcomes were occlusion, catheter-related sepsis, thrombosis, and adverse effects of heparin. To detect a 168-hour (1-week) difference in the duration of catheter use, 192 patients were needed. Kaplan-Meier and Cox regression analyses were performed. RESULTS: A total of 201 neonates were enrolled (heparin group: n = 100; control group: n = 101). Baseline demographics were similar between the groups. Duration of catheter use was longer in the infants in the heparin versus the placebo group. Study center, gender, birth weight, and type and position of the catheter were not predictors of duration of catheter use. For those in the heparin versus the placebo group, the incidence of elective catheter removal (therapy completed) was 63% vs 42%, of occlusion was 6% vs 31%, of thrombosis was 20% vs 21%, and of catheter-related sepsis was 10% vs 6%, respectively. No adverse events were noted. CONCLUSIONS: Heparin infusion prolonged the duration of peripherally inserted central venous catheter usability, which permitted a higher percentage of neonates to complete therapy without increasing adverse effects. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106250957 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A randomized, controlled trial of heparin versus placebo infusion to prolong the usability of peripherally placed percutaneous central venous catheters (PCVCs) in neonates: the HIP (Heparin Infusion for PCVC) Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shah+PS%22">Shah PS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kalyn+A%22">Kalyn A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Satodia+P%22">Satodia P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dunn+MS%22">Dunn MS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parvez+B%22">Parvez B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Daneman+A%22">Daneman A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salem+S%22">Salem S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glanc+P%22">Glanc P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ohlsson+A%22">Ohlsson A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shah+V%22">Shah V</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Jan2007, Vol. 119 Issue 1, pe284-91. 1p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Mechanical and infectious complications shorten the effective duration of peripherally inserted central venous catheters. Heparin use to prevent such complications and prolong the usability of peripherally inserted central venous catheters is inconclusive. OBJECTIVE: Our goal was to evaluate the effectiveness of heparin in prolonging the usability of peripherally inserted central venous catheters in neonates. DESIGN/METHODS: We performed a multicenter, randomized, controlled trial of heparin infusion (0.5 U/kg per hour) versus placebo for peripherally inserted central venous catheters in neonates. The primary outcome was duration of catheter use. Secondary outcomes were occlusion, catheter-related sepsis, thrombosis, and adverse effects of heparin. To detect a 168-hour (1-week) difference in the duration of catheter use, 192 patients were needed. Kaplan-Meier and Cox regression analyses were performed. RESULTS: A total of 201 neonates were enrolled (heparin group: n = 100; control group: n = 101). Baseline demographics were similar between the groups. Duration of catheter use was longer in the infants in the heparin versus the placebo group. Study center, gender, birth weight, and type and position of the catheter were not predictors of duration of catheter use. For those in the heparin versus the placebo group, the incidence of elective catheter removal (therapy completed) was 63% vs 42%, of occlusion was 6% vs 31%, of thrombosis was 20% vs 21%, and of catheter-related sepsis was 10% vs 6%, respectively. No adverse events were noted. CONCLUSIONS: Heparin infusion prolonged the duration of peripherally inserted central venous catheter usability, which permitted a higher percentage of neonates to complete therapy without increasing adverse effects. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2006-0529 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e284 Titles: – TitleFull: A randomized, controlled trial of heparin versus placebo infusion to prolong the usability of peripherally placed percutaneous central venous catheters (PCVCs) in neonates: the HIP (Heparin Infusion for PCVC) Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shah PS – PersonEntity: Name: NameFull: Kalyn A – PersonEntity: Name: NameFull: Satodia P – PersonEntity: Name: NameFull: Dunn MS – PersonEntity: Name: NameFull: Parvez B – PersonEntity: Name: NameFull: Daneman A – PersonEntity: Name: NameFull: Salem S – PersonEntity: Name: NameFull: Glanc P – PersonEntity: Name: NameFull: Ohlsson A – PersonEntity: Name: NameFull: Shah V IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 119 – Type: issue Value: 1 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
