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Impact of prenatal cocaine exposure on child behavior problems through school age.

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Title: Impact of prenatal cocaine exposure on child behavior problems through school age.
Authors: Bada HS (AUTHOR), Das A (AUTHOR), Bauer CR (AUTHOR), Shankaran S (AUTHOR), Lester B (AUTHOR), LaGasse L (AUTHOR), Hammond J (AUTHOR), Wright LL (AUTHOR), Higgins R (AUTHOR)
Source: Pediatrics. Feb2007, Vol. 119 Issue 2, pe348-59. 1p.
Abstract: OBJECTIVE: We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS: The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS: High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS: Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impact of prenatal cocaine exposure on child behavior problems through school age.
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  Data: <searchLink fieldCode="AR" term="%22Bada+HS%22">Bada HS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Das+A%22">Das A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bauer+CR%22">Bauer CR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shankaran+S%22">Shankaran S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lester+B%22">Lester B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22LaGasse+L%22">LaGasse L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hammond+J%22">Hammond J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wright+LL%22">Wright LL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Higgins+R%22">Higgins R</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Feb2007, Vol. 119 Issue 2, pe348-59. 1p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: OBJECTIVE: We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS: The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS: High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS: Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1542/peds.2006-1404
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