Infectious disease morbidity among young HIV-1-exposed but uninfected infants in Latin American and Caribbean countries: the National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study.
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| Title: | Infectious disease morbidity among young HIV-1-exposed but uninfected infants in Latin American and Caribbean countries: the National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study. |
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| Authors: | Mussi-Pinhata MM (AUTHOR), Freimanis L (AUTHOR), Yamamoto AY (AUTHOR), Korelitz J (AUTHOR), Pinto JA (AUTHOR), Cruz MLS (AUTHOR), Losso MH (AUTHOR), Read JS (AUTHOR), US National Institute of Child Health and Human Development International Site Development. Initiative Perinatal Study Group (CORPORATE AUTHOR) |
| Source: | Pediatrics. Mar2007, Vol. 119 Issue 3, pe694-704. 1p. |
| Abstract: | OBJECTIVE: The goal was to describe the frequency, characteristics, and correlates of infectious disease morbidity during the first 6 months of life among HIV-1-exposed but uninfected infants. METHODS: The study population consisted of infants enrolled in the National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study who were HIV-1 uninfected and had follow-up data through the 6-month study visit. Definitive and presumed infections were recorded at study visits (birth, 6-12 weeks, and 6 months). RESULTS: Of 462 HIV-1-uninfected infants with 11,644 child-weeks of observation, 283 experienced > or = 1 infection. These 283 infants experienced 522 infections (1.8 infections per infant). The overall incidence rate of infections was 4.5 cases per 100 child-weeks of observation. Overall, the most common infections were skin or mucous membrane infections (1.9 cases per 100 child-weeks) and respiratory tract infections (1.7 cases per 100 child-weeks). Thirty-six percent of infants had > 1 respiratory tract infection (1.8 cases per 100 child-weeks). Incidence rates of upper and lower respiratory tract infections were similar (0.89 cases per 100 child-weeks and 0.9 cases per 100 child-weeks, respectively). Cutaneous and/or oral candidiasis occurred in 48 neonates (10.3%) and 92 older infants (19.3%). Early neonatal sepsis was diagnosed in 12 infants (26.0 cases per 1000 infants). Overall, 81 of 462 (17.5%) infants were hospitalized with an infection. Infants with lower respiratory tract infections were hospitalized frequently (40.7%). The occurrence of > or = 1 neonatal infection was associated with more-advanced maternal HIV-1 disease, tobacco use during pregnancy, infant anemia, and crowding. Lower maternal CD4+ cell counts, receipt of intrapartum antibiotic treatment, and country of residence were associated with postneonatal infections. CONCLUSIONS: Close monitoring of HIV-1-exposed infants, especially those who are anemic at birth or whose mothers have more-advanced HIV-1 disease or who smoked during pregnancy, remains important. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106275868 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Infectious disease morbidity among young HIV-1-exposed but uninfected infants in Latin American and Caribbean countries: the National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mussi-Pinhata+MM%22">Mussi-Pinhata MM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Freimanis+L%22">Freimanis L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yamamoto+AY%22">Yamamoto AY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korelitz+J%22">Korelitz J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pinto+JA%22">Pinto JA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cruz+MLS%22">Cruz MLS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Losso+MH%22">Losso MH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Read+JS%22">Read JS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22US+National+Institute+of+Child+Health+and+Human+Development+International+Site+Development%2E+Initiative+Perinatal+Study+Group%22">US National Institute of Child Health and Human Development International Site Development. Initiative Perinatal Study Group</searchLink> (CORPORATE AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Mar2007, Vol. 119 Issue 3, pe694-704. 1p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVE: The goal was to describe the frequency, characteristics, and correlates of infectious disease morbidity during the first 6 months of life among HIV-1-exposed but uninfected infants. METHODS: The study population consisted of infants enrolled in the National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study who were HIV-1 uninfected and had follow-up data through the 6-month study visit. Definitive and presumed infections were recorded at study visits (birth, 6-12 weeks, and 6 months). RESULTS: Of 462 HIV-1-uninfected infants with 11,644 child-weeks of observation, 283 experienced > or = 1 infection. These 283 infants experienced 522 infections (1.8 infections per infant). The overall incidence rate of infections was 4.5 cases per 100 child-weeks of observation. Overall, the most common infections were skin or mucous membrane infections (1.9 cases per 100 child-weeks) and respiratory tract infections (1.7 cases per 100 child-weeks). Thirty-six percent of infants had > 1 respiratory tract infection (1.8 cases per 100 child-weeks). Incidence rates of upper and lower respiratory tract infections were similar (0.89 cases per 100 child-weeks and 0.9 cases per 100 child-weeks, respectively). Cutaneous and/or oral candidiasis occurred in 48 neonates (10.3%) and 92 older infants (19.3%). Early neonatal sepsis was diagnosed in 12 infants (26.0 cases per 1000 infants). Overall, 81 of 462 (17.5%) infants were hospitalized with an infection. Infants with lower respiratory tract infections were hospitalized frequently (40.7%). The occurrence of > or = 1 neonatal infection was associated with more-advanced maternal HIV-1 disease, tobacco use during pregnancy, infant anemia, and crowding. Lower maternal CD4+ cell counts, receipt of intrapartum antibiotic treatment, and country of residence were associated with postneonatal infections. CONCLUSIONS: Close monitoring of HIV-1-exposed infants, especially those who are anemic at birth or whose mothers have more-advanced HIV-1 disease or who smoked during pregnancy, remains important. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2006-1856 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e694 Titles: – TitleFull: Infectious disease morbidity among young HIV-1-exposed but uninfected infants in Latin American and Caribbean countries: the National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mussi-Pinhata MM – PersonEntity: Name: NameFull: Freimanis L – PersonEntity: Name: NameFull: Yamamoto AY – PersonEntity: Name: NameFull: Korelitz J – PersonEntity: Name: NameFull: Pinto JA – PersonEntity: Name: NameFull: Cruz MLS – PersonEntity: Name: NameFull: Losso MH – PersonEntity: Name: NameFull: Read JS – PersonEntity: Name: NameFull: US National Institute of Child Health and Human Development International Site Development. Initiative Perinatal Study Group IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 119 – Type: issue Value: 3 Titles: – TitleFull: Pediatrics Type: main |
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