Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet.
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| Title: | Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. |
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| Authors: | O'Brien FE (AUTHOR), Iwata O (AUTHOR), Thornton JS (AUTHOR), De Vita E (AUTHOR), Sellwood MW (AUTHOR), Iwata S (AUTHOR), Sakata YS (AUTHOR), Charman S (AUTHOR), Ordidge R (AUTHOR), Cady EB (AUTHOR), Wyatt JS (AUTHOR), Robertson NJ (AUTHOR) |
| Source: | Pediatrics. May2006, Vol. 117 Issue 5, p1549-1559. 11p. |
| Abstract: | OBJECTIVES: Fundamental questions remain about the precise temperature providing optimal neuroprotection after perinatal hypoxia-ischemia (HI). Furthermore, if hypothermia delays the onset of the neurotoxic cascade and the secondary impairment in cerebral energy generation, the 'latent phase' may be prolonged, thus extending the period when additional treatments may be effective. The aims of this study were to investigate the effects of delayed systemic cooling at either 33 degrees C or 35 degrees C on the following: (1) latent-phase duration, and (2) cerebral metabolism during secondary energy failure itself, in the 48-hour period after transient HI. METHODS: Piglets were randomly assigned to the following: (1) HI-normothermic (HI-n) rectal temperature (Trectal; n = 12), (2) HI-Trectal 35 degrees C (HI-35; n = 7), and (3) HI-Trectal 33 degrees C (HI-33; n = 10). Groups were cooled to the target Trectal between 2 and 26 hours after HI. Serial magnetic resonance spectroscopy was performed over 48 hours. The effect of cooling on secondary energy failure severity (indexed by the nucleotide triphosphate/exchangeable phosphate pool [NTP/EPP] and phosphocreatine/inorganic phosphate [PCr/Pi] ratios) was assessed. RESULTS: Compared with HI-n, HI-35 and HI-33 had a longer NTP/EPP latent phase and during the entire study duration had higher mean NTP/EPP and PCr/Pi. The latent phase (both PCr/Pi and NTP/EPP) and the whole-brain cerebral energetics were similar for HI-35 and HI-33. During the hypothermic period, compared with HI-n, PCr/Pi was preserved in the cooled groups, but this advantage was not maintained after rewarming. Compared with HI-n, HI-35 and HI-33 had higher NTP/EPP after rewarming. CONCLUSIONS: Whole-body hypothermia for 24 hours at either 35 or 33 degrees C, commenced 2 hours after resuscitation, prolonged the NTP/EPP latent phase and reduced the overall secondary falls in mean PCr/Pi and NTP/EPP during 48 hours after HI. Reducing the temperature from 35 to 33 degrees C neither increased mean PCr/Pi and NTP/EPP nor further lengthened the latent phase. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106317526 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22O'Brien+FE%22">O'Brien FE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iwata+O%22">Iwata O</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thornton+JS%22">Thornton JS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Vita+E%22">De Vita E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sellwood+MW%22">Sellwood MW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iwata+S%22">Iwata S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sakata+YS%22">Sakata YS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Charman+S%22">Charman S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ordidge+R%22">Ordidge R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cady+EB%22">Cady EB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wyatt+JS%22">Wyatt JS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robertson+NJ%22">Robertson NJ</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. May2006, Vol. 117 Issue 5, p1549-1559. 11p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVES: Fundamental questions remain about the precise temperature providing optimal neuroprotection after perinatal hypoxia-ischemia (HI). Furthermore, if hypothermia delays the onset of the neurotoxic cascade and the secondary impairment in cerebral energy generation, the 'latent phase' may be prolonged, thus extending the period when additional treatments may be effective. The aims of this study were to investigate the effects of delayed systemic cooling at either 33 degrees C or 35 degrees C on the following: (1) latent-phase duration, and (2) cerebral metabolism during secondary energy failure itself, in the 48-hour period after transient HI. METHODS: Piglets were randomly assigned to the following: (1) HI-normothermic (HI-n) rectal temperature (Trectal; n = 12), (2) HI-Trectal 35 degrees C (HI-35; n = 7), and (3) HI-Trectal 33 degrees C (HI-33; n = 10). Groups were cooled to the target Trectal between 2 and 26 hours after HI. Serial magnetic resonance spectroscopy was performed over 48 hours. The effect of cooling on secondary energy failure severity (indexed by the nucleotide triphosphate/exchangeable phosphate pool [NTP/EPP] and phosphocreatine/inorganic phosphate [PCr/Pi] ratios) was assessed. RESULTS: Compared with HI-n, HI-35 and HI-33 had a longer NTP/EPP latent phase and during the entire study duration had higher mean NTP/EPP and PCr/Pi. The latent phase (both PCr/Pi and NTP/EPP) and the whole-brain cerebral energetics were similar for HI-35 and HI-33. During the hypothermic period, compared with HI-n, PCr/Pi was preserved in the cooled groups, but this advantage was not maintained after rewarming. Compared with HI-n, HI-35 and HI-33 had higher NTP/EPP after rewarming. CONCLUSIONS: Whole-body hypothermia for 24 hours at either 35 or 33 degrees C, commenced 2 hours after resuscitation, prolonged the NTP/EPP latent phase and reduced the overall secondary falls in mean PCr/Pi and NTP/EPP during 48 hours after HI. Reducing the temperature from 35 to 33 degrees C neither increased mean PCr/Pi and NTP/EPP nor further lengthened the latent phase. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2005-1649 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1549 Titles: – TitleFull: Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: O'Brien FE – PersonEntity: Name: NameFull: Iwata O – PersonEntity: Name: NameFull: Thornton JS – PersonEntity: Name: NameFull: De Vita E – PersonEntity: Name: NameFull: Sellwood MW – PersonEntity: Name: NameFull: Iwata S – PersonEntity: Name: NameFull: Sakata YS – PersonEntity: Name: NameFull: Charman S – PersonEntity: Name: NameFull: Ordidge R – PersonEntity: Name: NameFull: Cady EB – PersonEntity: Name: NameFull: Wyatt JS – PersonEntity: Name: NameFull: Robertson NJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 117 – Type: issue Value: 5 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
