Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants.
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| Title: | Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. |
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| Authors: | Guillet R (AUTHOR), Stoll BJ (AUTHOR), Cotten CM (AUTHOR), Gantz M (AUTHOR), McDonald S (AUTHOR), Poole WK (AUTHOR), Phelps DL (AUTHOR), US National Institute of Child Health and Human Development Neonatal Research Network (CORPORATE AUTHOR) |
| Source: | Pediatrics. Feb2006, Vol. 117 Issue 2, pe137-42. 1p. |
| Abstract: | OBJECTIVE. We sought to determine if an association exists between the use of histamine-2 receptor (H2) blockers and the incidence of necrotizing enterocolitis (NEC) in infants of 401 to 1500 g in birth weight.STUDY DESIGN. Data from the National Institute of Child Health and Human Development Neonatal Research Network very low birth weight (401-1500 g) registry from September 1998 to December 2001 were analyzed. The relation between the diagnosis of NEC (Bell stage II or greater) and antecedent H2-blocker treatment was determined by using case-control methodology. Conditional logistic regression was implemented, controlling for gender, site of birth (outborn versus inborn), Apgar score of <7 at 5 minutes, and postnatal steroids.RESULTS. Of 11072 infants who survived for at least 12 hours, 787 (7.1%) developed NEC (11.5% of infants 401-750 g, 9.1% of infants 751-1000 g, 6.0% of infants 1001-1250 g, and 3.9% of infants 1251-1500 g). Antecedent H2-blocker use was associated with an increased incidence of NEC (P < .0001).CONCLUSIONS. H2-blocker therapy was associated with higher rates of NEC, which is in agreement with a previous randomized trial of acidification of infant feeds that resulted in a decreased incidence of NEC. In combination, these data support the hypothesis that gastric pH level may be a factor in the pathogenesis of NEC. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106434959 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Guillet+R%22">Guillet R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stoll+BJ%22">Stoll BJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cotten+CM%22">Cotten CM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gantz+M%22">Gantz M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McDonald+S%22">McDonald S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poole+WK%22">Poole WK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Phelps+DL%22">Phelps DL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22US+National+Institute+of+Child+Health+and+Human+Development+Neonatal+Research+Network%22">US National Institute of Child Health and Human Development Neonatal Research Network</searchLink> (CORPORATE AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Feb2006, Vol. 117 Issue 2, pe137-42. 1p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVE. We sought to determine if an association exists between the use of histamine-2 receptor (H2) blockers and the incidence of necrotizing enterocolitis (NEC) in infants of 401 to 1500 g in birth weight.STUDY DESIGN. Data from the National Institute of Child Health and Human Development Neonatal Research Network very low birth weight (401-1500 g) registry from September 1998 to December 2001 were analyzed. The relation between the diagnosis of NEC (Bell stage II or greater) and antecedent H2-blocker treatment was determined by using case-control methodology. Conditional logistic regression was implemented, controlling for gender, site of birth (outborn versus inborn), Apgar score of <7 at 5 minutes, and postnatal steroids.RESULTS. Of 11072 infants who survived for at least 12 hours, 787 (7.1%) developed NEC (11.5% of infants 401-750 g, 9.1% of infants 751-1000 g, 6.0% of infants 1001-1250 g, and 3.9% of infants 1251-1500 g). Antecedent H2-blocker use was associated with an increased incidence of NEC (P < .0001).CONCLUSIONS. H2-blocker therapy was associated with higher rates of NEC, which is in agreement with a previous randomized trial of acidification of infant feeds that resulted in a decreased incidence of NEC. In combination, these data support the hypothesis that gastric pH level may be a factor in the pathogenesis of NEC. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2005-1543 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e137 Titles: – TitleFull: Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Guillet R – PersonEntity: Name: NameFull: Stoll BJ – PersonEntity: Name: NameFull: Cotten CM – PersonEntity: Name: NameFull: Gantz M – PersonEntity: Name: NameFull: McDonald S – PersonEntity: Name: NameFull: Poole WK – PersonEntity: Name: NameFull: Phelps DL – PersonEntity: Name: NameFull: US National Institute of Child Health and Human Development Neonatal Research Network IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 117 – Type: issue Value: 2 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
