Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease?
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| Title: | Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? |
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| Authors: | Bitar M (AUTHOR), Mahfouz R (AUTHOR), Soweid A (AUTHOR), Racoubian E (AUTHOR), Ghasham M (AUTHOR), Zaatari G (AUTHOR), Fuleihan N (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Feb2006, Vol. 126 Issue 2, p154-159. 6p. |
| Abstract: | OBJECTIVE: There is growing interest in studying the presence of HP in the upper aerodigestive tract. It was shown in several pilot studies that it colonizes the area, while other authors found no evidence of its presence there and a third group of authors believed that it had only a transient presence there. In this study we investigated a possible role for HP in middle ear disease in children. MATERIAL AND METHODS: Consecutive patients undergoing myringotomy and adenoidectomy for chronic otitis media with effusion or recurrent otitis media were enrolled. Middle ear fluids were cultured on three types of agar plate (Brucella + laked horse blood; Brucella + sheep blood; and chocolate). A double polymerase chain reaction (PCR) was run to detect urease-C and adhesion subunit genes. Rapid urease enzyme testing and PCR were used on the adenoid specimens. Parents were interviewed regarding symptoms suggestive of gastroesophageal reflux in their children. RESULTS: Eighteen patients were enrolled in the study (mean age 4.4 years; age range 3-8 years) with an equal gender distribution. All 28 middle ear fluid cultures were negative in all 3 media. Twenty-one of the 28 samples contained DNA, yet PCR revealed that none of them belonged to HP. Ten of the 13 adenoid specimens obtained were positive on rapid urease testing, but none on PCR. Seven of the 18 patients had at least 1 symptom suggestive of gastroesophageal reflux during the 6 months preceding the study but this did not have an impact on any of the results. CONCLUSION: There was no evidence from this study that Helicobacter pylori (HP) colonizes the nasopharynx of children with middle ear disease, whether dyspeptic or not. There is also no apparent role for this bacterium in middle ear pathology. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106456868 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bitar+M%22">Bitar M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahfouz+R%22">Mahfouz R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soweid+A%22">Soweid A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Racoubian+E%22">Racoubian E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghasham+M%22">Ghasham M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zaatari+G%22">Zaatari G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fuleihan+N%22">Fuleihan N</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Feb2006, Vol. 126 Issue 2, p154-159. 6p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVE: There is growing interest in studying the presence of HP in the upper aerodigestive tract. It was shown in several pilot studies that it colonizes the area, while other authors found no evidence of its presence there and a third group of authors believed that it had only a transient presence there. In this study we investigated a possible role for HP in middle ear disease in children. MATERIAL AND METHODS: Consecutive patients undergoing myringotomy and adenoidectomy for chronic otitis media with effusion or recurrent otitis media were enrolled. Middle ear fluids were cultured on three types of agar plate (Brucella + laked horse blood; Brucella + sheep blood; and chocolate). A double polymerase chain reaction (PCR) was run to detect urease-C and adhesion subunit genes. Rapid urease enzyme testing and PCR were used on the adenoid specimens. Parents were interviewed regarding symptoms suggestive of gastroesophageal reflux in their children. RESULTS: Eighteen patients were enrolled in the study (mean age 4.4 years; age range 3-8 years) with an equal gender distribution. All 28 middle ear fluid cultures were negative in all 3 media. Twenty-one of the 28 samples contained DNA, yet PCR revealed that none of them belonged to HP. Ten of the 13 adenoid specimens obtained were positive on rapid urease testing, but none on PCR. Seven of the 18 patients had at least 1 symptom suggestive of gastroesophageal reflux during the 6 months preceding the study but this did not have an impact on any of the results. CONCLUSION: There was no evidence from this study that Helicobacter pylori (HP) colonizes the nasopharynx of children with middle ear disease, whether dyspeptic or not. There is also no apparent role for this bacterium in middle ear pathology. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106456868 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00016480500312679 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 154 Titles: – TitleFull: Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bitar M – PersonEntity: Name: NameFull: Mahfouz R – PersonEntity: Name: NameFull: Soweid A – PersonEntity: Name: NameFull: Racoubian E – PersonEntity: Name: NameFull: Ghasham M – PersonEntity: Name: NameFull: Zaatari G – PersonEntity: Name: NameFull: Fuleihan N IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00016489 Numbering: – Type: volume Value: 126 – Type: issue Value: 2 Titles: – TitleFull: Acta Oto-Laryngologica Type: main |
| ResultId | 1 |
