Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade.
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| Title: | Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade. |
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| Authors: | Fullmer JJ (AUTHOR), Fan LL (AUTHOR), Dishop MK (AUTHOR), Rodgers C (AUTHOR), Krance R (AUTHOR) |
| Source: | Pediatrics. Sep2005, Vol. 116 Issue 3, p767-770. 4p. |
| Abstract: | Bronchiolitis obliterans (BO) in children is a rare, inflammatory/fibrosing process involving the small airways that often results in progressive, irreversible obstructive pulmonary disease. Because treatment has focused mainly on supportive care and generally unsuccessful immunosuppression, children with BO experience significant morbidity and mortality. We report a case of biopsy-proven BO after bone marrow transplantation in a child who, after failed corticosteroid therapy, was treated with infliximab, a monoclonal antibody with binding specificity for human tumor necrosis factor-alpha. With initiation of treatment, her pulmonary symptoms and radiographic and spirometric evidence of BO resolved. Nine months later, she remains asymptomatic and shows no evidence of pulmonary decompensation. This case illustrates a successful treatment of BO with selective tumor necrosis factor-alpha blockade. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106531537 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fullmer+JJ%22">Fullmer JJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan+LL%22">Fan LL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dishop+MK%22">Dishop MK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodgers+C%22">Rodgers C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krance+R%22">Krance R</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Sep2005, Vol. 116 Issue 3, p767-770. 4p. – Name: Abstract Label: Abstract Group: Ab Data: Bronchiolitis obliterans (BO) in children is a rare, inflammatory/fibrosing process involving the small airways that often results in progressive, irreversible obstructive pulmonary disease. Because treatment has focused mainly on supportive care and generally unsuccessful immunosuppression, children with BO experience significant morbidity and mortality. We report a case of biopsy-proven BO after bone marrow transplantation in a child who, after failed corticosteroid therapy, was treated with infliximab, a monoclonal antibody with binding specificity for human tumor necrosis factor-alpha. With initiation of treatment, her pulmonary symptoms and radiographic and spirometric evidence of BO resolved. Nine months later, she remains asymptomatic and shows no evidence of pulmonary decompensation. This case illustrates a successful treatment of BO with selective tumor necrosis factor-alpha blockade. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106531537 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.2005-0806 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 767 Titles: – TitleFull: Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fullmer JJ – PersonEntity: Name: NameFull: Fan LL – PersonEntity: Name: NameFull: Dishop MK – PersonEntity: Name: NameFull: Rodgers C – PersonEntity: Name: NameFull: Krance R IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 116 – Type: issue Value: 3 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
