Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide.
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| Title: | Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide. |
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| Authors: | Singer M (AUTHOR), Coluzzi F (AUTHOR), O'Brien A (AUTHOR), Clapp LH (AUTHOR), Singer, Mervyn (AUTHOR), Coluzzi, Flaminia (AUTHOR), O'Brien, Alastair (AUTHOR), Clapp, Lucie H (AUTHOR) |
| Source: | Lancet. 5/28/2005, Vol. 365 Issue 9474, p1873-1875. 3p. |
| Abstract: | We describe three critically ill patients who received drugs with K(ATP) channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and cardiovascular disturbances. Administration of the sulfonylurea-receptor inhibitor glibenclamide promptly reversed these abnormalities. Over the past 3 years, we have seen this syndrome and response in five patients taking nicorandil, ciclosporin, or isoflurane, which suggests that this disorder arises more frequently than is currently realised. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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