Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation.
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| Title: | Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation. |
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| Authors: | Lindauer RJL (AUTHOR), Vlieger E (AUTHOR), Jalink M (AUTHOR), Olff M (AUTHOR), Carlier IVE (AUTHOR), Majoie CBL (AUTHOR), Den Heeten GJ (AUTHOR), Gersons BPR (AUTHOR) |
| Source: | Psychological Medicine. Oct2005, Vol. 35 Issue 10, p1421-1431. 11p. |
| Abstract: | BACKGROUND: Magnetic resonance imaging (MRI) studies have especially reported smaller hippocampal volume in patients with post-traumatic stress disorder (PTSD), most of them war or sexual abuse victims. The present study compares the hippocampal volumes of out-patients with PTSD who had low co-morbidity rates to those of trauma-exposed control subjects without PTSD, and measures hippocampal volume changes in these patients after brief eclectic psychotherapy. We hypothesized that smaller hippocampal volumes are specific to PTSD and that hippocampal volume changes after effective psychotherapy would be measurable. METHOD: Eighteen patients with PTSD and 14 traumatized control subjects were examined with MRI. In a randomized clinical trial, the PTSD patients were assigned to treatment (n = 9) or waiting-list group (n = 9). After the former received psychotherapy for 4 months, the MRI was repeated on both PTSD groups. Three temporal lobe structures were manually segmented: hippocampus, amygdala, and parahippocampal gyrus. Volumetric analysis was used to measure grey matter, white matter, and cerebrospinal fluid. RESULTS: PTSD patients had significantly smaller hippocampal volumes at baseline (total 13.8%, right 13.5%, left 14.1%) compared to the control subjects. After effective psychotherapy, however, no volume changes were found in the smaller hippocampi. CONCLUSIONS: We confirmed previous findings of smaller hippocampal volume in PTSD in a new population made up of out-patients who experienced different types of traumas, reducing co-morbidity to a minimum. Smaller hippocampal volumes did not change after effective psychotherapy, even while symptoms resolved. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106540439 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lindauer+RJL%22">Lindauer RJL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vlieger+E%22">Vlieger E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jalink+M%22">Jalink M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Olff+M%22">Olff M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carlier+IVE%22">Carlier IVE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Majoie+CBL%22">Majoie CBL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Den+Heeten+GJ%22">Den Heeten GJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gersons+BPR%22">Gersons BPR</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Oct2005, Vol. 35 Issue 10, p1421-1431. 11p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Magnetic resonance imaging (MRI) studies have especially reported smaller hippocampal volume in patients with post-traumatic stress disorder (PTSD), most of them war or sexual abuse victims. The present study compares the hippocampal volumes of out-patients with PTSD who had low co-morbidity rates to those of trauma-exposed control subjects without PTSD, and measures hippocampal volume changes in these patients after brief eclectic psychotherapy. We hypothesized that smaller hippocampal volumes are specific to PTSD and that hippocampal volume changes after effective psychotherapy would be measurable. METHOD: Eighteen patients with PTSD and 14 traumatized control subjects were examined with MRI. In a randomized clinical trial, the PTSD patients were assigned to treatment (n = 9) or waiting-list group (n = 9). After the former received psychotherapy for 4 months, the MRI was repeated on both PTSD groups. Three temporal lobe structures were manually segmented: hippocampus, amygdala, and parahippocampal gyrus. Volumetric analysis was used to measure grey matter, white matter, and cerebrospinal fluid. RESULTS: PTSD patients had significantly smaller hippocampal volumes at baseline (total 13.8%, right 13.5%, left 14.1%) compared to the control subjects. After effective psychotherapy, however, no volume changes were found in the smaller hippocampi. CONCLUSIONS: We confirmed previous findings of smaller hippocampal volume in PTSD in a new population made up of out-patients who experienced different types of traumas, reducing co-morbidity to a minimum. Smaller hippocampal volumes did not change after effective psychotherapy, even while symptoms resolved. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/s0033291705005246 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1421 Titles: – TitleFull: Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lindauer RJL – PersonEntity: Name: NameFull: Vlieger E – PersonEntity: Name: NameFull: Jalink M – PersonEntity: Name: NameFull: Olff M – PersonEntity: Name: NameFull: Carlier IVE – PersonEntity: Name: NameFull: Majoie CBL – PersonEntity: Name: NameFull: Den Heeten GJ – PersonEntity: Name: NameFull: Gersons BPR IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 00332917 Numbering: – Type: volume Value: 35 – Type: issue Value: 10 Titles: – TitleFull: Psychological Medicine Type: main |
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