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Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging, and Body Composition Study.

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Title: Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging, and Body Composition Study.
Authors: Colbert LH (AUTHOR), Visser M (AUTHOR), Simonsick EM (AUTHOR), Tracy RP (AUTHOR), Newman AB (AUTHOR), Kritchevsky SB (AUTHOR), Pahor M (AUTHOR), Taaffe DR (AUTHOR), Brach J (AUTHOR), Rubin S (AUTHOR), Harris TB (AUTHOR)
Source: Journal of the American Geriatrics Society. Jul2004, Vol. 52 Issue 7, p1098-1104. 7p.
Abstract: Objectives: To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use. Design: Cross-sectional study, using baseline data from the Health, Aging and Body Composition Study. Setting: Metropolitan areas surrounding Pittsburgh, Pennsylvania, and Memphis, Tennessee. Participants: Black and white, well-functioning men and women (N=3,075), aged 70 to 79. Measurements: Interviewer-administered questionnaires of previous-week household, walking, exercise, and occupational/volunteer physical activities. Analysis of covariance was used to examine the association between activity level and serum C-reactive protein (CRP), interleukin-6 (IL-6), and plasma tumor necrosis factor alpha (TNFalpha) with covariate adjustment. Antioxidant supplement use (multivitamin, vitamins E or C, beta carotene) was evaluated as an effect modifier of the association. Results: Higher levels of exercise were associated with lower levels of CRP (P<.01), IL-6 (P<.001), and TNFalpha (P=.02) (e.g., CRP=1.95 mg/L for no exercise and 1.72 for >180 min/wk). Adjustment for body fatness attenuated the associations somewhat. Use of antioxidant supplements modified the CRP (P(interaction)=.01) and IL-6 (P(interaction)=.08) associations such that concentrations were low in those taking supplements (e.g., CRP=1.79-1.84 across exercise levels) and higher in nonsupplement users who did no exercise (2.03) than in those who did the most (1.72). Among nonexercisers, higher levels of other physical activity were related to lower levels of CRP (P<.01) and IL-6 (P=.02) but not TNFalpha (P=.36), even after accounting for body fat. Conclusion: Inflammatory markers are lower in older adults with higher levels of exercise and nonexercise activity and in antioxidant supplement users regardless of exercise level. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging, and Body Composition Study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Colbert+LH%22&quot;&gt;Colbert LH&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Visser+M%22&quot;&gt;Visser M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Simonsick+EM%22&quot;&gt;Simonsick EM&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tracy+RP%22&quot;&gt;Tracy RP&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Newman+AB%22&quot;&gt;Newman AB&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kritchevsky+SB%22&quot;&gt;Kritchevsky SB&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pahor+M%22&quot;&gt;Pahor M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Taaffe+DR%22&quot;&gt;Taaffe DR&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brach+J%22&quot;&gt;Brach J&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rubin+S%22&quot;&gt;Rubin S&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Harris+TB%22&quot;&gt;Harris TB&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+the+American+Geriatrics+Society%22&quot;&gt;Journal of the American Geriatrics Society&lt;/searchLink&gt;. Jul2004, Vol. 52 Issue 7, p1098-1104. 7p.
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  Data: Objectives: To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use. Design: Cross-sectional study, using baseline data from the Health, Aging and Body Composition Study. Setting: Metropolitan areas surrounding Pittsburgh, Pennsylvania, and Memphis, Tennessee. Participants: Black and white, well-functioning men and women (N=3,075), aged 70 to 79. Measurements: Interviewer-administered questionnaires of previous-week household, walking, exercise, and occupational/volunteer physical activities. Analysis of covariance was used to examine the association between activity level and serum C-reactive protein (CRP), interleukin-6 (IL-6), and plasma tumor necrosis factor alpha (TNFalpha) with covariate adjustment. Antioxidant supplement use (multivitamin, vitamins E or C, beta carotene) was evaluated as an effect modifier of the association. Results: Higher levels of exercise were associated with lower levels of CRP (P&lt;.01), IL-6 (P&lt;.001), and TNFalpha (P=.02) (e.g., CRP=1.95 mg/L for no exercise and 1.72 for &gt;180 min/wk). Adjustment for body fatness attenuated the associations somewhat. Use of antioxidant supplements modified the CRP (P(interaction)=.01) and IL-6 (P(interaction)=.08) associations such that concentrations were low in those taking supplements (e.g., CRP=1.79-1.84 across exercise levels) and higher in nonsupplement users who did no exercise (2.03) than in those who did the most (1.72). Among nonexercisers, higher levels of other physical activity were related to lower levels of CRP (P&lt;.01) and IL-6 (P=.02) but not TNFalpha (P=.36), even after accounting for body fat. Conclusion: Inflammatory markers are lower in older adults with higher levels of exercise and nonexercise activity and in antioxidant supplement users regardless of exercise level. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1532-5415.2004.52307.x
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              Text: Jul2004
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