View in EDS

The tumor necrosis factor alpha -- 308G greater than A polymorphism is associated with dementia in the oldest old.

Saved in:
Bibliographic Details
Title: The tumor necrosis factor alpha -- 308G greater than A polymorphism is associated with dementia in the oldest old.
Authors: Bruunsgaard H (AUTHOR), Benfield TL (AUTHOR), Andersen-Ranberg K (AUTHOR), Hjelmborg JB (AUTHOR), Pedersen AN (AUTHOR), Schroll M (AUTHOR), Pedersen BK (AUTHOR), Jeune B (AUTHOR)
Source: Journal of the American Geriatrics Society. Aug2004, Vol. 52 Issue 8, p1361-1366. 6p.
Abstract: OBJECTIVES: To test the hypothesis that the tumor necrosis factor (TNF) -308 G>A promoter gene polymorphism is a risk factor in age-related dementia and longevity. DESIGN: A cross-sectional and a longitudinal study. SETTING: A population-based sample of Danish centenarians. PARTICIPANTS: One hundred-year-old Danes (n=122) from 'The Longitudinal Study of Danish Centenarians.' Octogenarians (n=174) and healthy volunteers aged 18 to 30 (n=47) served as reference groups. METHODS: Whether the distribution of TNF -308 GG/GA/AA genotypes were different in centenarians than in younger age groups was investigated (Fischer exact test). Furthermore, whether the TNF -308 G>A polymorphism was associated with the prevalence of dementia (logistic regression analysis), the plasma level of TNF-alpha (analysis of variance), and mortality in the following 5 years (Cox regression analysis) within the cohort of centenarians was tested. RESULTS: The distribution of TNF -308 genotypes was not different across the three different age groups, but the GA genotype was associated with decreased prevalence of dementia in centenarians. The few centenarians with AA carrier status had higher mortality risk and tended to show higher plasma levels of TNF-alpha, but the significance was questionable due to a low number of subjects with this genotype. CONCLUSION: It is possible that the TNF -308 A allele is maintained during aging because subjects who are heterozygous for this polymorphism possess the optimal inflammatory response with regard to protection against age-related neurodegeneration. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 106560695
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The tumor necrosis factor alpha -- 308G greater than A polymorphism is associated with dementia in the oldest old.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bruunsgaard+H%22">Bruunsgaard H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benfield+TL%22">Benfield TL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andersen-Ranberg+K%22">Andersen-Ranberg K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hjelmborg+JB%22">Hjelmborg JB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pedersen+AN%22">Pedersen AN</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schroll+M%22">Schroll M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pedersen+BK%22">Pedersen BK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jeune+B%22">Jeune B</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+American+Geriatrics+Society%22">Journal of the American Geriatrics Society</searchLink>. Aug2004, Vol. 52 Issue 8, p1361-1366. 6p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: OBJECTIVES: To test the hypothesis that the tumor necrosis factor (TNF) -308 G>A promoter gene polymorphism is a risk factor in age-related dementia and longevity. DESIGN: A cross-sectional and a longitudinal study. SETTING: A population-based sample of Danish centenarians. PARTICIPANTS: One hundred-year-old Danes (n=122) from 'The Longitudinal Study of Danish Centenarians.' Octogenarians (n=174) and healthy volunteers aged 18 to 30 (n=47) served as reference groups. METHODS: Whether the distribution of TNF -308 GG/GA/AA genotypes were different in centenarians than in younger age groups was investigated (Fischer exact test). Furthermore, whether the TNF -308 G>A polymorphism was associated with the prevalence of dementia (logistic regression analysis), the plasma level of TNF-alpha (analysis of variance), and mortality in the following 5 years (Cox regression analysis) within the cohort of centenarians was tested. RESULTS: The distribution of TNF -308 genotypes was not different across the three different age groups, but the GA genotype was associated with decreased prevalence of dementia in centenarians. The few centenarians with AA carrier status had higher mortality risk and tended to show higher plasma levels of TNF-alpha, but the significance was questionable due to a low number of subjects with this genotype. CONCLUSION: It is possible that the TNF -308 A allele is maintained during aging because subjects who are heterozygous for this polymorphism possess the optimal inflammatory response with regard to protection against age-related neurodegeneration. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106560695
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1532-5415.2004.52369.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1361
    Titles:
      – TitleFull: The tumor necrosis factor alpha -- 308G greater than A polymorphism is associated with dementia in the oldest old.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bruunsgaard H
      – PersonEntity:
          Name:
            NameFull: Benfield TL
      – PersonEntity:
          Name:
            NameFull: Andersen-Ranberg K
      – PersonEntity:
          Name:
            NameFull: Hjelmborg JB
      – PersonEntity:
          Name:
            NameFull: Pedersen AN
      – PersonEntity:
          Name:
            NameFull: Schroll M
      – PersonEntity:
          Name:
            NameFull: Pedersen BK
      – PersonEntity:
          Name:
            NameFull: Jeune B
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2004
              Type: published
              Y: 2004
          Identifiers:
            – Type: issn-print
              Value: 00028614
          Numbering:
            – Type: volume
              Value: 52
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Journal of the American Geriatrics Society
              Type: main
ResultId 1