View in EDS HTML Full Text PDF Full Text

Association between antenatal cytokine production and the development of atopy and asthma at age 6 years.

Saved in:
Bibliographic Details
Title: Association between antenatal cytokine production and the development of atopy and asthma at age 6 years.
Authors: Macaubas C (AUTHOR), de Klerk NH (AUTHOR), Holt BJ (AUTHOR), Wee C (AUTHOR), Kendall G (AUTHOR), Firth M (AUTHOR), Sly PD (AUTHOR), Holt PG (AUTHOR), Macaubas, C (AUTHOR), de Klerk, N H (AUTHOR), Holt, B J (AUTHOR), Wee, C (AUTHOR), Kendall, G (AUTHOR), Firth, M (AUTHOR), Sly, P D (AUTHOR), Holt, P G (AUTHOR)
Source: Lancet. 10/11/2003, Vol. 362 Issue 9391, p1192-1197. 6p.
Abstract: Background: Various lines of evidence suggest that antenatal factors are important in determining susceptibility to atopy and asthma. One possible mechanism is cytokines, production of which in the placenta is high throughout gestation and which protect placental integrity via control of local immunological homoeostasis. We investigated antenatal cytokine concentrations in a prospective birth cohort, intensively monitored for atopy and asthma outcomes at age 6 years.Methods: Cryopreserved cord-blood serum samples from 407 children were assayed for interleukins 4, 5, 6, 10, 12, and 13, interferon gamma, and tumour necrosis factor alpha (TNFalpha). Associations between family, antenatal, and perinatal factors, cord-blood cytokine concentrations, and atopy or asthma outcomes were analysed by logistic regression. Causal effects of cytokines on outcomes were estimated by propensity scores based on family, antenatal, and perinatal factors.Findings: Detectable cord-blood concentrations of interleukin 4 and interferon gamma were each associated with lower risk of physician-diagnosed asthma (adjusted odds ratios 0.60 [95% CI 0.37-0.99] and 0.60 [0.37-0.97] respectively), current asthma (0.59 [0.33-1.00] and 0.39 [0.22-0.71]), and current wheeze (0.55 [0.32-0.93] and 0.52 [0.31-0.90]) and atopy (sensitisation to some inhalant allergens) outcomes at 6 years. High concentrations of TNFalpha were associated with lower risk of atopy but not with asthma risk. These associations were broadly unaltered by propensity-score adjustment. Maternal smoking was associated with higher risk of both wheeze at 6 years and lower concentrations of interleukin 4 and interferon gamma in cord blood.Interpretation: The mechanism underlying attenuated T-helper-1/T-helper-2 cytokine production in high-risk children also apparently operates in control of cytokine production in the fetoplacental unit. The finding that this mechanism is dysregulated by maternal smoking suggests it is a target for antenatal environmental factors relevant to asthma aetiology. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 106571338
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Association between antenatal cytokine production and the development of atopy and asthma at age 6 years.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Macaubas+C%22">Macaubas C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Klerk+NH%22">de Klerk NH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Holt+BJ%22">Holt BJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wee+C%22">Wee C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kendall+G%22">Kendall G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Firth+M%22">Firth M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sly+PD%22">Sly PD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Holt+PG%22">Holt PG</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Macaubas%2C+C%22">Macaubas, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Klerk%2C+N+H%22">de Klerk, N H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Holt%2C+B+J%22">Holt, B J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wee%2C+C%22">Wee, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kendall%2C+G%22">Kendall, G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Firth%2C+M%22">Firth, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sly%2C+P+D%22">Sly, P D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Holt%2C+P+G%22">Holt, P G</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 10/11/2003, Vol. 362 Issue 9391, p1192-1197. 6p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>Various lines of evidence suggest that antenatal factors are important in determining susceptibility to atopy and asthma. One possible mechanism is cytokines, production of which in the placenta is high throughout gestation and which protect placental integrity via control of local immunological homoeostasis. We investigated antenatal cytokine concentrations in a prospective birth cohort, intensively monitored for atopy and asthma outcomes at age 6 years.<bold>Methods: </bold>Cryopreserved cord-blood serum samples from 407 children were assayed for interleukins 4, 5, 6, 10, 12, and 13, interferon gamma, and tumour necrosis factor alpha (TNFalpha). Associations between family, antenatal, and perinatal factors, cord-blood cytokine concentrations, and atopy or asthma outcomes were analysed by logistic regression. Causal effects of cytokines on outcomes were estimated by propensity scores based on family, antenatal, and perinatal factors.<bold>Findings: </bold>Detectable cord-blood concentrations of interleukin 4 and interferon gamma were each associated with lower risk of physician-diagnosed asthma (adjusted odds ratios 0.60 [95% CI 0.37-0.99] and 0.60 [0.37-0.97] respectively), current asthma (0.59 [0.33-1.00] and 0.39 [0.22-0.71]), and current wheeze (0.55 [0.32-0.93] and 0.52 [0.31-0.90]) and atopy (sensitisation to some inhalant allergens) outcomes at 6 years. High concentrations of TNFalpha were associated with lower risk of atopy but not with asthma risk. These associations were broadly unaltered by propensity-score adjustment. Maternal smoking was associated with higher risk of both wheeze at 6 years and lower concentrations of interleukin 4 and interferon gamma in cord blood.<bold>Interpretation: </bold>The mechanism underlying attenuated T-helper-1/T-helper-2 cytokine production in high-risk children also apparently operates in control of cytokine production in the fetoplacental unit. The finding that this mechanism is dysregulated by maternal smoking suggests it is a target for antenatal environmental factors relevant to asthma aetiology. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106571338
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/s0140-6736(03)14542-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1192
    Titles:
      – TitleFull: Association between antenatal cytokine production and the development of atopy and asthma at age 6 years.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Macaubas C
      – PersonEntity:
          Name:
            NameFull: de Klerk NH
      – PersonEntity:
          Name:
            NameFull: Holt BJ
      – PersonEntity:
          Name:
            NameFull: Wee C
      – PersonEntity:
          Name:
            NameFull: Kendall G
      – PersonEntity:
          Name:
            NameFull: Firth M
      – PersonEntity:
          Name:
            NameFull: Sly PD
      – PersonEntity:
          Name:
            NameFull: Holt PG
      – PersonEntity:
          Name:
            NameFull: Macaubas, C
      – PersonEntity:
          Name:
            NameFull: de Klerk, N H
      – PersonEntity:
          Name:
            NameFull: Holt, B J
      – PersonEntity:
          Name:
            NameFull: Wee, C
      – PersonEntity:
          Name:
            NameFull: Kendall, G
      – PersonEntity:
          Name:
            NameFull: Firth, M
      – PersonEntity:
          Name:
            NameFull: Sly, P D
      – PersonEntity:
          Name:
            NameFull: Holt, P G
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 10
              Text: 10/11/2003
              Type: published
              Y: 2003
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 362
            – Type: issue
              Value: 9391
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1