Caesarean section and risk of unexplained stillbirth in subsequent pregnancy.

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Title: Caesarean section and risk of unexplained stillbirth in subsequent pregnancy.
Authors: Smith GCS (AUTHOR), Pell JP (AUTHOR), Dobbie R (AUTHOR), Smith, Gordon C S (AUTHOR), Pell, Jill P (AUTHOR), Dobbie, Richard (AUTHOR)
Source: Lancet. 11/29/2003, Vol. 362 Issue 9398, p1779-1784. 6p.
Abstract: Background: Caesarean section is associated with an increased risk of disorders of placentation in subsequent pregnancies, but effects on the rate of antepartum stillbirth are unknown. We aimed to establish whether previous caesarean delivery is associated with an increased risk of antepartum stillbirth.Methods: We linked pregnancy discharge data from the Scottish Morbidity Record (1980-98) and the Scottish Stillbirth and Infant Death Enquiry (1985-98). We estimated the relative risk of antepartum stillbirth in second pregnancies using time-to-event analyses.Findings: For 120633 singleton second births, there were 68 antepartum stillbirths in 17754 women previously delivered by caesarean section (2.39 per 10000 women per week) and 244 in 102879 women previously delivered vaginally (1.44; p<0.001). Risk of unexplained stillbirth associated with previous caesarean delivery differed significantly with gestational age (p=0.04); the excess risk was apparent from 34 weeks (hazard ratio 2.23 [95% CI 1.48-3.36]). Risk was not attenuated by adjustment for maternal characteristics or outcome of the first pregnancy (2.74 [1.74-4.30]). The absolute risk of unexplained stillbirth at or after 39 weeks' gestation was 1.1 per 1000 women who had had a previous caesarean section and 0.5 per 1000 in those who had not. The difference was due mostly to an excess of unexplained stillbirths among women previously delivered by caesarean section.Interpretation: Delivery by caesarean section in the first pregnancy could increase the risk of unexplained stillbirth in the second. In women with one previous caesarean delivery, the risk of unexplained antepartum stillbirth at or after 39 weeks' gestation is about double the risk of stillbirth or neonatal death from intrapartum uterine rupture. [ABSTRACT FROM AUTHOR]
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  Data: Caesarean section and risk of unexplained stillbirth in subsequent pregnancy.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Smith+GCS%22&quot;&gt;Smith GCS&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pell+JP%22&quot;&gt;Pell JP&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dobbie+R%22&quot;&gt;Dobbie R&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Smith%2C+Gordon+C+S%22&quot;&gt;Smith, Gordon C S&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pell%2C+Jill+P%22&quot;&gt;Pell, Jill P&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dobbie%2C+Richard%22&quot;&gt;Dobbie, Richard&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Lancet%22&quot;&gt;Lancet&lt;/searchLink&gt;. 11/29/2003, Vol. 362 Issue 9398, p1779-1784. 6p.
– Name: Abstract
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  Data: &lt;bold&gt;Background: &lt;/bold&gt;Caesarean section is associated with an increased risk of disorders of placentation in subsequent pregnancies, but effects on the rate of antepartum stillbirth are unknown. We aimed to establish whether previous caesarean delivery is associated with an increased risk of antepartum stillbirth.&lt;bold&gt;Methods: &lt;/bold&gt;We linked pregnancy discharge data from the Scottish Morbidity Record (1980-98) and the Scottish Stillbirth and Infant Death Enquiry (1985-98). We estimated the relative risk of antepartum stillbirth in second pregnancies using time-to-event analyses.&lt;bold&gt;Findings: &lt;/bold&gt;For 120633 singleton second births, there were 68 antepartum stillbirths in 17754 women previously delivered by caesarean section (2.39 per 10000 women per week) and 244 in 102879 women previously delivered vaginally (1.44; p&lt;0.001). Risk of unexplained stillbirth associated with previous caesarean delivery differed significantly with gestational age (p=0.04); the excess risk was apparent from 34 weeks (hazard ratio 2.23 [95% CI 1.48-3.36]). Risk was not attenuated by adjustment for maternal characteristics or outcome of the first pregnancy (2.74 [1.74-4.30]). The absolute risk of unexplained stillbirth at or after 39 weeks&#39; gestation was 1.1 per 1000 women who had had a previous caesarean section and 0.5 per 1000 in those who had not. The difference was due mostly to an excess of unexplained stillbirths among women previously delivered by caesarean section.&lt;bold&gt;Interpretation: &lt;/bold&gt;Delivery by caesarean section in the first pregnancy could increase the risk of unexplained stillbirth in the second. In women with one previous caesarean delivery, the risk of unexplained antepartum stillbirth at or after 39 weeks&#39; gestation is about double the risk of stillbirth or neonatal death from intrapartum uterine rupture. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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              Text: 11/29/2003
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              Y: 2003
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