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Correlation between different memory systems and striatal dopamine D2/D3 receptor density: a single photon emission computed tomography study.

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Title: Correlation between different memory systems and striatal dopamine D2/D3 receptor density: a single photon emission computed tomography study.
Authors: Chen PS (AUTHOR), Yang YK (AUTHOR), Lee Y (AUTHOR), Yeh TL (AUTHOR), Lee IH (AUTHOR), Chiu NT (AUTHOR), Chu CL (AUTHOR)
Source: Psychological Medicine. Feb2005, Vol. 35 Issue 2, p197-204. 8p.
Abstract: Objective. Although studies have indicated that the human basal ganglia have a specific role in different memory systems, the functional significance of the striatal dopamine activities for the basal ganglia remains less clear. This study assessed the relationship between measures of striatal dopamine activities and indices of different memory systems in healthy individuals.Method. Single photon emission computed tomography and [[1][2][3]I]IBZM (iodobenzamide) were used to assess the striatal dopamine D[2]/D[3] receptor density in 62 healthy volunteers aged between 19 and 61 years. All subjects underwent a Wechsler Memory Scale-Revised test.Results. Dopamine D[2]/D[3] receptor densities in the striatum decline with age. Stepwise regression analysis showed that verbal delayed recall and working memory account for most of the variance in dopamine D[2]/D[3] measurements. These relationships remain significantly after controlling for age effects.Conclusions. Brain striatal dopamine activities are also significantly associated with various memory systems, in addition to motor functions. This may explain why patients with neuropsychiatric disorders may have both memory and motor impairments. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Correlation between different memory systems and striatal dopamine D2/D3 receptor density: a single photon emission computed tomography study.
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  Data: <searchLink fieldCode="AR" term="%22Chen+PS%22">Chen PS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang+YK%22">Yang YK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee+Y%22">Lee Y</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yeh+TL%22">Yeh TL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee+IH%22">Lee IH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chiu+NT%22">Chiu NT</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chu+CL%22">Chu CL</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Feb2005, Vol. 35 Issue 2, p197-204. 8p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective. Although studies have indicated that the human basal ganglia have a specific role in different memory systems, the functional significance of the striatal dopamine activities for the basal ganglia remains less clear. This study assessed the relationship between measures of striatal dopamine activities and indices of different memory systems in healthy individuals.Method. Single photon emission computed tomography and [[1][2][3]I]IBZM (iodobenzamide) were used to assess the striatal dopamine D[2]/D[3] receptor density in 62 healthy volunteers aged between 19 and 61 years. All subjects underwent a Wechsler Memory Scale-Revised test.Results. Dopamine D[2]/D[3] receptor densities in the striatum decline with age. Stepwise regression analysis showed that verbal delayed recall and working memory account for most of the variance in dopamine D[2]/D[3] measurements. These relationships remain significantly after controlling for age effects.Conclusions. Brain striatal dopamine activities are also significantly associated with various memory systems, in addition to motor functions. This may explain why patients with neuropsychiatric disorders may have both memory and motor impairments. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Feb2005
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