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Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed.

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Title: Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed.
Authors: Kieseppä T (AUTHOR), Tuulio-Henriksson A (AUTHOR), Haukka J (AUTHOR), Van Erp T (AUTHOR), Glahn D (AUTHOR), Cannon TD (AUTHOR), Partonen T (AUTHOR), Kaprio J (AUTHOR), Lönnqvist J (AUTHOR)
Source: Psychological Medicine. Feb2005, Vol. 35 Issue 2, p205-215. 11p.
Abstract: Background. Euthymic bipolar-I disorder (BP I) patients and their siblings have shown impairments in verbal learning and memory functions compared with controls, suggesting that these impairments may be genetic in origin. Reduced information-processing speed has been associated with impaired memory in the elderly, and recently in schizophrenia. The authors compared verbal learning and memory functioning in twins with BP I and co-twins to control twins, and examined whether the observed deficits are related to information-processing speed.Method. Finnish Medical and Population Registers and Twin Cohorts were used to identify the BP I and control twins. Neuropsychological tests assessing verbal learning and memory, working memory, facial recognition, visual memory, and information-processing speed were administered to 26 BP I twins, 19 non-bipolar co-twins, and 114 controls. Group differences were analyzed by generalized estimation equation modeling.Results. BP I patients, but not co-twins, showed impairments in all memory tests compared with controls. Female co-twins showed impairment in verbal learning and memory. Information-processing speed had a significant effect on encoding and learning efficiency.Conclusions. This study showed for the first time that information-processing speed is related to memory functioning and verbal learning in BP I in a population-based, representative and euthymic sample. Furthermore, the data support the view that defects in verbal memory may be related to the genetic factors predisposing to BP I in females. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed.
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  Data: <searchLink fieldCode="AR" term="%22Kieseppä+T%22">Kieseppä T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tuulio-Henriksson+A%22">Tuulio-Henriksson A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haukka+J%22">Haukka J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Erp+T%22">Van Erp T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glahn+D%22">Glahn D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cannon+TD%22">Cannon TD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Partonen+T%22">Partonen T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaprio+J%22">Kaprio J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lönnqvist+J%22">Lönnqvist J</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Feb2005, Vol. 35 Issue 2, p205-215. 11p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background. Euthymic bipolar-I disorder (BP I) patients and their siblings have shown impairments in verbal learning and memory functions compared with controls, suggesting that these impairments may be genetic in origin. Reduced information-processing speed has been associated with impaired memory in the elderly, and recently in schizophrenia. The authors compared verbal learning and memory functioning in twins with BP I and co-twins to control twins, and examined whether the observed deficits are related to information-processing speed.Method. Finnish Medical and Population Registers and Twin Cohorts were used to identify the BP I and control twins. Neuropsychological tests assessing verbal learning and memory, working memory, facial recognition, visual memory, and information-processing speed were administered to 26 BP I twins, 19 non-bipolar co-twins, and 114 controls. Group differences were analyzed by generalized estimation equation modeling.Results. BP I patients, but not co-twins, showed impairments in all memory tests compared with controls. Female co-twins showed impairment in verbal learning and memory. Information-processing speed had a significant effect on encoding and learning efficiency.Conclusions. This study showed for the first time that information-processing speed is related to memory functioning and verbal learning in BP I in a population-based, representative and euthymic sample. Furthermore, the data support the view that defects in verbal memory may be related to the genetic factors predisposing to BP I in females. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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