Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study.
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| Title: | Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study. |
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| Authors: | Ng KH (AUTHOR), Chong D (AUTHOR), Wong CK (AUTHOR), Ong HT (AUTHOR), Lee CY (AUTHOR), Lee BW (AUTHOR), Shek LP (AUTHOR) |
| Source: | Pediatrics. 2004 Feb Supplement, Vol. 113 Issue 2, pe116-21. 1p. |
| Abstract: | OBJECTIVE: Allergic rhinitis is common and on the rise. Antihistamines are the mainstay of treatment and are the most commonly prescribed drugs in Singapore. Treatment-related sedation and its effect on cognition are a major concern. First- and second-generation antihistamines show varying degrees of sedation, but to date, objective studies in children are lacking. The objective of this study was to assess the sedating effect of cetirizine (second-generation antihistamine) and chlorpheniramine (first-generation antihistamine) compared with placebo using an objective neurophysiological test. METHODS: This was a prospective, double-blind, placebo-controlled, randomized, single-dose, 3-way crossover study. Twenty-four children aged 7 to 14 years with allergic rhinitis completed the study. All children were randomly allocated to medication sequences and received 3 different drugs on 3 different days, at least 1 week apart. The P300 event-related potential was used as an objective test of sedation. Subjective assessment was by a visual analog scale. RESULTS: Chlorpheniramine and cetirizine increased P300 latency when compared with baseline. No significant increase was obtained with placebo. The significant increase in P300 latency was not accompanied by significant change in subjective somnolence as measured by the visual analog scale. CONCLUSION: We have shown that cetirizine has sedative properties in children. The lack of correlation between P300 latency and the visual analog scale indicates that sedation induced by these drugs may not be subjectively noted. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106611291 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ng+KH%22">Ng KH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chong+D%22">Chong D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wong+CK%22">Wong CK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ong+HT%22">Ong HT</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee+CY%22">Lee CY</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee+BW%22">Lee BW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shek+LP%22">Shek LP</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. 2004 Feb Supplement, Vol. 113 Issue 2, pe116-21. 1p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVE: Allergic rhinitis is common and on the rise. Antihistamines are the mainstay of treatment and are the most commonly prescribed drugs in Singapore. Treatment-related sedation and its effect on cognition are a major concern. First- and second-generation antihistamines show varying degrees of sedation, but to date, objective studies in children are lacking. The objective of this study was to assess the sedating effect of cetirizine (second-generation antihistamine) and chlorpheniramine (first-generation antihistamine) compared with placebo using an objective neurophysiological test. METHODS: This was a prospective, double-blind, placebo-controlled, randomized, single-dose, 3-way crossover study. Twenty-four children aged 7 to 14 years with allergic rhinitis completed the study. All children were randomly allocated to medication sequences and received 3 different drugs on 3 different days, at least 1 week apart. The P300 event-related potential was used as an objective test of sedation. Subjective assessment was by a visual analog scale. RESULTS: Chlorpheniramine and cetirizine increased P300 latency when compared with baseline. No significant increase was obtained with placebo. The significant increase in P300 latency was not accompanied by significant change in subjective somnolence as measured by the visual analog scale. CONCLUSION: We have shown that cetirizine has sedative properties in children. The lack of correlation between P300 latency and the visual analog scale indicates that sedation induced by these drugs may not be subjectively noted. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106611291 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.113.2.e116 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e116 Titles: – TitleFull: Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ng KH – PersonEntity: Name: NameFull: Chong D – PersonEntity: Name: NameFull: Wong CK – PersonEntity: Name: NameFull: Ong HT – PersonEntity: Name: NameFull: Lee CY – PersonEntity: Name: NameFull: Lee BW – PersonEntity: Name: NameFull: Shek LP IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 02 Text: 2004 Feb Supplement Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 113 – Type: issue Value: 2 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
