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Can hyperbaric oxygen therapy reduce breast cancer treatment-related lymphedema? A pilot study.

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Title: Can hyperbaric oxygen therapy reduce breast cancer treatment-related lymphedema? A pilot study.
Authors: Teas J (AUTHOR), Cunningham JE (AUTHOR), Cone L (AUTHOR), Jansen K (AUTHOR), Raghavan SK (AUTHOR), Nitcheva DK (AUTHOR), Xie D (AUTHOR), Butler WM (AUTHOR)
Source: Journal of Women's Health (15409996). Nov2004, Vol. 13 Issue 9, p1008-1018. 11p.
Subjects: Breast cancer, Cancer in women, Hyperbaric oxygenation, Lymphedema, Oncology, Cancer treatment
Abstract: OBJECTIVE: Arm lymphedema after surgery or radiation for breast cancer is common, causing pain and limitation of activities. Previous reports of hyperbaric oxygen (HBO) therapy for breast edema led us to consider the use of HBO therapy for arm lymphedema. METHODS: Ten healthy postmenopausal women (age 58 +/- 5.7 years) with persistent (9.4 years +/- 9.1 years) arm lymphedema following breast cancer surgery and radiation (n = 10) plus chemotherapy (n = 7) received 20 HBO treatments (90 minutes at 2.0 ATA five times a week for 4 weeks). End points included changes in upper extremity volume, platelet counts, plasma levels of vascular endothelial growth factor (VEGF), and lymph angiogenic-associated vascular endothelial growth factor-C (VEGF-C). Lymphedema volume (LV) was defined as the volume of the unaffected arm subtracted from the volume of the affected arm. RESULTS: We observed a 38% average reduction in hand lymphedema (-7.4 ml, 11.6 SD, range -30-+8 ml, p = 0.076, 95% confidence interval -15.7-0.9 ml) at the end of HBO, which was independent of changes in body weight. For those who benefited (n = 8), the reduction was persistent from the end of treatment to a final measurement an average of 14.2 months after the last HBO treatment. However, total LV did not change significantly. VEGF-C increased from baseline (p = 0.004) before treatment 20, suggesting HBO had begun to stimulate this growth factor. CONCLUSIONS: Future studies should explore the effects of a greater number of HBO treatments on lymphedema, with more patients. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Can hyperbaric oxygen therapy reduce breast cancer treatment-related lymphedema? A pilot study.
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  Data: <searchLink fieldCode="AR" term="%22Teas+J%22">Teas J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cunningham+JE%22">Cunningham JE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cone+L%22">Cone L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jansen+K%22">Jansen K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Raghavan+SK%22">Raghavan SK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nitcheva+DK%22">Nitcheva DK</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie+D%22">Xie D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Butler+WM%22">Butler WM</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Women's+Health+%2815409996%29%22">Journal of Women's Health (15409996)</searchLink>. Nov2004, Vol. 13 Issue 9, p1008-1018. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Breast+cancer%22">Breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+in+women%22">Cancer in women</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperbaric+oxygenation%22">Hyperbaric oxygenation</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphedema%22">Lymphedema</searchLink><br /><searchLink fieldCode="DE" term="%22Oncology%22">Oncology</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: OBJECTIVE: Arm lymphedema after surgery or radiation for breast cancer is common, causing pain and limitation of activities. Previous reports of hyperbaric oxygen (HBO) therapy for breast edema led us to consider the use of HBO therapy for arm lymphedema. METHODS: Ten healthy postmenopausal women (age 58 +/- 5.7 years) with persistent (9.4 years +/- 9.1 years) arm lymphedema following breast cancer surgery and radiation (n = 10) plus chemotherapy (n = 7) received 20 HBO treatments (90 minutes at 2.0 ATA five times a week for 4 weeks). End points included changes in upper extremity volume, platelet counts, plasma levels of vascular endothelial growth factor (VEGF), and lymph angiogenic-associated vascular endothelial growth factor-C (VEGF-C). Lymphedema volume (LV) was defined as the volume of the unaffected arm subtracted from the volume of the affected arm. RESULTS: We observed a 38% average reduction in hand lymphedema (-7.4 ml, 11.6 SD, range -30-+8 ml, p = 0.076, 95% confidence interval -15.7-0.9 ml) at the end of HBO, which was independent of changes in body weight. For those who benefited (n = 8), the reduction was persistent from the end of treatment to a final measurement an average of 14.2 months after the last HBO treatment. However, total LV did not change significantly. VEGF-C increased from baseline (p = 0.004) before treatment 20, suggesting HBO had begun to stimulate this growth factor. CONCLUSIONS: Future studies should explore the effects of a greater number of HBO treatments on lymphedema, with more patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1089/jwh.2004.13.1008
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        Text: English
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        Type: general
      – SubjectFull: Cancer in women
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      – SubjectFull: Hyperbaric oxygenation
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      – SubjectFull: Lymphedema
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      – SubjectFull: Oncology
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      – SubjectFull: Cancer treatment
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              Text: Nov2004
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