Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents.
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| Title: | Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. |
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| Authors: | Paul IM (AUTHOR), Yoder KE (AUTHOR), Crowell KR (AUTHOR), Shaffer ML (AUTHOR), McMillan HS (AUTHOR), Carlson LC (AUTHOR), Dilworth DA (AUTHOR), Berlin CM Jr. (AUTHOR) |
| Source: | Pediatrics. 2004 Jul Suppl, Vol. 114 Issue 1, pe85-90. 1p. |
| Abstract: | OBJECTIVES: To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved sleep quality when their children receive the medications when compared with placebo. METHODS: Parents of 100 children with upper respiratory infections were questioned to assess the frequency, severity, and bothersome nature of the nocturnal cough. Their answers were recorded on 2 consecutive days, initially on the day of presentation, when no medication had been given the previous evening, and then again on the subsequent day, when either medication or placebo was given before bedtime. Sleep quality for both the child and the parent were also assessed for both nights. RESULTS: For the entire cohort, all outcomes were significantly improved on the second night of the study when either medication or placebo was given. However, neither diphenhydramine nor dextromethorphan produced a superior benefit when compared with placebo for any of the outcomes studied. Insomnia was reported more frequently in those who were given dextromethorphan, and drowsiness was reported more commonly in those who were given diphenhydramine. CONCLUSIONS: Diphenhydramine and dextromethorphan are not superior to placebo in providing nocturnal symptom relief for children with cough and sleep difficulty as a result of an upper respiratory infection. Furthermore, the medications given to children do not result in improved quality of sleep for their parents when compared with placebo. Each clinician should consider these findings, the potential for adverse effects, and the individual and cumulative costs of the drugs before recommending them to families. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106627003 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Paul+IM%22">Paul IM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yoder+KE%22">Yoder KE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crowell+KR%22">Crowell KR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shaffer+ML%22">Shaffer ML</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McMillan+HS%22">McMillan HS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carlson+LC%22">Carlson LC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dilworth+DA%22">Dilworth DA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berlin+CM+Jr%2E%22">Berlin CM Jr.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. 2004 Jul Suppl, Vol. 114 Issue 1, pe85-90. 1p. – Name: Abstract Label: Abstract Group: Ab Data: OBJECTIVES: To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved sleep quality when their children receive the medications when compared with placebo. METHODS: Parents of 100 children with upper respiratory infections were questioned to assess the frequency, severity, and bothersome nature of the nocturnal cough. Their answers were recorded on 2 consecutive days, initially on the day of presentation, when no medication had been given the previous evening, and then again on the subsequent day, when either medication or placebo was given before bedtime. Sleep quality for both the child and the parent were also assessed for both nights. RESULTS: For the entire cohort, all outcomes were significantly improved on the second night of the study when either medication or placebo was given. However, neither diphenhydramine nor dextromethorphan produced a superior benefit when compared with placebo for any of the outcomes studied. Insomnia was reported more frequently in those who were given dextromethorphan, and drowsiness was reported more commonly in those who were given diphenhydramine. CONCLUSIONS: Diphenhydramine and dextromethorphan are not superior to placebo in providing nocturnal symptom relief for children with cough and sleep difficulty as a result of an upper respiratory infection. Furthermore, the medications given to children do not result in improved quality of sleep for their parents when compared with placebo. Each clinician should consider these findings, the potential for adverse effects, and the individual and cumulative costs of the drugs before recommending them to families. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106627003 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.114.1.e85 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: e85 Titles: – TitleFull: Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Paul IM – PersonEntity: Name: NameFull: Yoder KE – PersonEntity: Name: NameFull: Crowell KR – PersonEntity: Name: NameFull: Shaffer ML – PersonEntity: Name: NameFull: McMillan HS – PersonEntity: Name: NameFull: Carlson LC – PersonEntity: Name: NameFull: Dilworth DA – PersonEntity: Name: NameFull: Berlin CM Jr. IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 07 Text: 2004 Jul Suppl Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 114 – Type: issue Value: 1 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
