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Frequency of infective [sic] endocarditis among infants and children with Staphylococcus aureus bacteremia.

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Title: Frequency of infective [sic] endocarditis among infants and children with Staphylococcus aureus bacteremia.
Authors: Valente AM (AUTHOR), Jain R (AUTHOR), Scheurer M (AUTHOR), Fowler VG Jr. (AUTHOR), Corey GR (AUTHOR), Bengur AR (AUTHOR), Sanders S (AUTHOR), Li JS (AUTHOR)
Source: Pediatrics. Jan2005 Supplement P, Vol. 115, pe15-9. 1p.
Abstract: PURPOSE: The prevalence of infective endocarditis (IE) among children with Staphylococcus aureus bacteremia (SAB) is unknown. The objective of this study was to determine prospectively the prevalence of IE among pediatric patients with SAB in a large tertiary care center. METHODS: Between July 1998 and June 2001, all children who developed SAB whose parent/guardian signed informed consent underwent echocardiography. Clinical and follow-up results were collected prospectively. Endocarditis was classified according to the modified Duke criteria. RESULTS: Fifty-one children developed SAB during the study interval. Definite (6 patients [11.8%]) or possible (4 patients [7.8%]) IE was present in 10 of 51 (20%) children with SAB. Most children (73%) developed bacteremia as a consequence of an infected intravascular device. Children with underlying congenital heart disease had a significantly higher prevalence of definite or possible IE, compared with those with structurally normal hearts (53% vs 3%). All patients with definite IE had multiple positive blood cultures. Mortality was high among patients with and without IE (40% vs 12%). CONCLUSIONS: In this study, the prevalence of definite IE among children with SAB was approximately 12% and was frequently associated with congenital heart disease and multiple positive blood cultures. The mortality for children with SAB and definite or possible S aureus IE is high. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Frequency of infective [sic] endocarditis among infants and children with Staphylococcus aureus bacteremia.
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  Data: <searchLink fieldCode="AR" term="%22Valente+AM%22">Valente AM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jain+R%22">Jain R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scheurer+M%22">Scheurer M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fowler+VG+Jr%2E%22">Fowler VG Jr.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Corey+GR%22">Corey GR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bengur+AR%22">Bengur AR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sanders+S%22">Sanders S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li+JS%22">Li JS</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Jan2005 Supplement P, Vol. 115, pe15-9. 1p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: PURPOSE: The prevalence of infective endocarditis (IE) among children with Staphylococcus aureus bacteremia (SAB) is unknown. The objective of this study was to determine prospectively the prevalence of IE among pediatric patients with SAB in a large tertiary care center. METHODS: Between July 1998 and June 2001, all children who developed SAB whose parent/guardian signed informed consent underwent echocardiography. Clinical and follow-up results were collected prospectively. Endocarditis was classified according to the modified Duke criteria. RESULTS: Fifty-one children developed SAB during the study interval. Definite (6 patients [11.8%]) or possible (4 patients [7.8%]) IE was present in 10 of 51 (20%) children with SAB. Most children (73%) developed bacteremia as a consequence of an infected intravascular device. Children with underlying congenital heart disease had a significantly higher prevalence of definite or possible IE, compared with those with structurally normal hearts (53% vs 3%). All patients with definite IE had multiple positive blood cultures. Mortality was high among patients with and without IE (40% vs 12%). CONCLUSIONS: In this study, the prevalence of definite IE among children with SAB was approximately 12% and was frequently associated with congenital heart disease and multiple positive blood cultures. The mortality for children with SAB and definite or possible S aureus IE is high. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1542/peds.2004-1152
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      – Code: eng
        Text: English
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      – TitleFull: Frequency of infective [sic] endocarditis among infants and children with Staphylococcus aureus bacteremia.
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            NameFull: Valente AM
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              Text: Jan2005 Supplement P
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              Y: 2005
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