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Postmenopausal hormone therapy and migraine headache.

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Title: Postmenopausal hormone therapy and migraine headache.
Authors: Misakian AL (AUTHOR), Langer RD (AUTHOR), Bensenor IM (AUTHOR), Cook NR (AUTHOR), Manson JE (AUTHOR), Buring JE (AUTHOR), Rexrode KM (AUTHOR)
Source: Journal of Women's Health (15409996). Dec2003, Vol. 12 Issue 10, p1027-1036. 10p.
Subjects: Hormone therapy, Women, Migraine, Headache, Estrogen, Progestational hormones
Abstract: Background: Estrogen withdrawal has been described as a trigger for migraine headache, and some studies suggest that estrogen and progestin may exacerbate migraine. No population-based studies have examined the association between hormone therapy (HT) and migraine among postmenopausal women. Methods: To examine the association between HT and migraine headache in postmenopausal women, we used self-report of HT use, HT characteristics, and migraine headache within the past year among 17,107 postmenopausal female health professionals enrolled in the Women's Health Study. Results: Analyses were restricted to the 17,107 of 21,788 postmenopausal women who were postmenopausal at baseline and who were never (38.5%) or current (61.5%) users of HT. Of these, 1,909 (11.2%) experienced migraine headache within the last year. Women with migraine headache were significantly younger, had a younger age at menopause, were more likely to have had a surgical menopause, and were more likely to be current users of HT. After adjusting for age, race, smoking, alcohol use, ever use of oral contraception, age at menopause, and menopause type, the odds ratio (OR) for migraine headache was 1.42 (95% CI 1.24-1.62) for women who were current users of HT compared with never users. ORs were similar for users of estrogen alone (OR 1.39, 95% CI 1.14-1.69) and users of both estrogen and progestin (OR 1.41, 95% CI 1.22-1.63). Conclusions: In this cross-sectional study, current HT use was associated with higher rates of migraine headache than nonuse. Clinical trials are needed to determine if HT increases the incidence of migraine in postmenopausal women. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Postmenopausal hormone therapy and migraine headache.
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  Data: <searchLink fieldCode="AR" term="%22Misakian+AL%22">Misakian AL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Langer+RD%22">Langer RD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bensenor+IM%22">Bensenor IM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cook+NR%22">Cook NR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manson+JE%22">Manson JE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buring+JE%22">Buring JE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rexrode+KM%22">Rexrode KM</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Women's+Health+%2815409996%29%22">Journal of Women's Health (15409996)</searchLink>. Dec2003, Vol. 12 Issue 10, p1027-1036. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Hormone+therapy%22">Hormone therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Women%22">Women</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Headache%22">Headache</searchLink><br /><searchLink fieldCode="DE" term="%22Estrogen%22">Estrogen</searchLink><br /><searchLink fieldCode="DE" term="%22Progestational+hormones%22">Progestational hormones</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Estrogen withdrawal has been described as a trigger for migraine headache, and some studies suggest that estrogen and progestin may exacerbate migraine. No population-based studies have examined the association between hormone therapy (HT) and migraine among postmenopausal women. Methods: To examine the association between HT and migraine headache in postmenopausal women, we used self-report of HT use, HT characteristics, and migraine headache within the past year among 17,107 postmenopausal female health professionals enrolled in the Women's Health Study. Results: Analyses were restricted to the 17,107 of 21,788 postmenopausal women who were postmenopausal at baseline and who were never (38.5%) or current (61.5%) users of HT. Of these, 1,909 (11.2%) experienced migraine headache within the last year. Women with migraine headache were significantly younger, had a younger age at menopause, were more likely to have had a surgical menopause, and were more likely to be current users of HT. After adjusting for age, race, smoking, alcohol use, ever use of oral contraception, age at menopause, and menopause type, the odds ratio (OR) for migraine headache was 1.42 (95% CI 1.24-1.62) for women who were current users of HT compared with never users. ORs were similar for users of estrogen alone (OR 1.39, 95% CI 1.14-1.69) and users of both estrogen and progestin (OR 1.41, 95% CI 1.22-1.63). Conclusions: In this cross-sectional study, current HT use was associated with higher rates of migraine headache than nonuse. Clinical trials are needed to determine if HT increases the incidence of migraine in postmenopausal women. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1089/154099903322643956
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        Text: English
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        Type: general
      – SubjectFull: Women
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      – SubjectFull: Migraine
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      – SubjectFull: Headache
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      – SubjectFull: Estrogen
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              Text: Dec2003
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