Experimenter-defined quit dates for smoking cessation: adherence improves outcomes for women but not for men.

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Bibliographic Details
Title:	Experimenter-defined quit dates for smoking cessation: adherence improves outcomes for women but not for men.
Authors:	Borrelli B (AUTHOR), Papandonatos G (AUTHOR), Spring B (AUTHOR), Hitsman B (AUTHOR), Niaura R (AUTHOR)
Source:	Addiction. Mar2004, Vol. 99 Issue 3, p378-385. 8p.
Abstract:	AIMS: Smoking cessation treatment trials often require that smokers quit on or before a protocol-defined date. The goals of this paper were to: (1) identify factors associated with adherence to a protocol-defined quit date and (2) determine whether such adherence predicts cessation outcome (relapse). DESIGN: A quasi-experimental secondary analysis of data collected from a randomized placebo-controlled trial of fluoxetine (60 mg or 30 mg) versus placebo for smoking cessation. SETTING AND PARTICIPANTS: Clinic-based smoking cessation treatment program comprising 989 non-depressed smokers. INTERVENTION: Participants received cognitive behavioral therapy for smoking cessation and either study medication or placebo for 10 weeks. They were required to set a quit date within 2 weeks of their second study visit (by visit 4). FINDINGS: Significant predictors of quit date adherence were low nicotine dependence and active drug treatment. High-dose fluoxetine (60 mg) and male gender were protective against relapse. Adherence to quit date was not an independent predictor of relapse; instead there was a significant interaction between quit date adherence and gender. Among non-adherers to the quit date, women were more than 2.5 times as likely as men to relapse; among adherers to the quit date, women were only 1.3 times as likely as men to relapse. CONCLUSIONS: Although women were more likely than men to relapse regardless of quit date adherence, adherence was strongly protective against relapse for women. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	AIMS: Smoking cessation treatment trials often require that smokers quit on or before a protocol-defined date. The goals of this paper were to: (1) identify factors associated with adherence to a protocol-defined quit date and (2) determine whether such adherence predicts cessation outcome (relapse). DESIGN: A quasi-experimental secondary analysis of data collected from a randomized placebo-controlled trial of fluoxetine (60 mg or 30 mg) versus placebo for smoking cessation. SETTING AND PARTICIPANTS: Clinic-based smoking cessation treatment program comprising 989 non-depressed smokers. INTERVENTION: Participants received cognitive behavioral therapy for smoking cessation and either study medication or placebo for 10 weeks. They were required to set a quit date within 2 weeks of their second study visit (by visit 4). FINDINGS: Significant predictors of quit date adherence were low nicotine dependence and active drug treatment. High-dose fluoxetine (60 mg) and male gender were protective against relapse. Adherence to quit date was not an independent predictor of relapse; instead there was a significant interaction between quit date adherence and gender. Among non-adherers to the quit date, women were more than 2.5 times as likely as men to relapse; among adherers to the quit date, women were only 1.3 times as likely as men to relapse. CONCLUSIONS: Although women were more likely than men to relapse regardless of quit date adherence, adherence was strongly protective against relapse for women. [ABSTRACT FROM AUTHOR]
ISSN:	09652140
DOI:	10.1111/j.1360-0443.2004.00648.x