Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells.
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| Title: | Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells. |
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| Authors: | Lin JG (AUTHOR), Chen GW (AUTHOR), Su CC (AUTHOR), Hung CF (AUTHOR), Yang CC (AUTHOR), Lee JH (AUTHOR), Chung JG (AUTHOR) |
| Source: | American Journal of Chinese Medicine. 2002, Vol. 30 Issue 2/3, p315-325. 11p. |
| Abstract: | Two components of garlic, diallyl sulfide (DAS) and diallyl disulfide (DADS), inhibited arylamine N-acetyltransferase (NAT) activity and 2-aminofluorene-DNA adduct in human promyelocytic leukemia cells (HL-60). The NAT activity was measured by high performance liquid chromatography assaying for amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF). Cellular cytosols and intact cell suspensions were assayed. The inhibition of NAT activity and 2-AF-DNA adduct formation in human leukemia cells by DAS and DADS were dose-dependent and were directly proportional. The data also indicated that DAS and DADS decrease the apparent values of Km and Vmax from human leukemia cells in both assays. This is the first report of garlic components affecting human leukemia cell NAT activity and 2-AF-DNA adduct formation. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 106797489 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lin+JG%22">Lin JG</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen+GW%22">Chen GW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Su+CC%22">Su CC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hung+CF%22">Hung CF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang+CC%22">Yang CC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee+JH%22">Lee JH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung+JG%22">Chung JG</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2002, Vol. 30 Issue 2/3, p315-325. 11p. – Name: Abstract Label: Abstract Group: Ab Data: Two components of garlic, diallyl sulfide (DAS) and diallyl disulfide (DADS), inhibited arylamine N-acetyltransferase (NAT) activity and 2-aminofluorene-DNA adduct in human promyelocytic leukemia cells (HL-60). The NAT activity was measured by high performance liquid chromatography assaying for amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF). Cellular cytosols and intact cell suspensions were assayed. The inhibition of NAT activity and 2-AF-DNA adduct formation in human leukemia cells by DAS and DADS were dose-dependent and were directly proportional. The data also indicated that DAS and DADS decrease the apparent values of Km and Vmax from human leukemia cells in both assays. This is the first report of garlic components affecting human leukemia cell NAT activity and 2-AF-DNA adduct formation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1142/s0192415x02000338 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 315 Titles: – TitleFull: Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lin JG – PersonEntity: Name: NameFull: Chen GW – PersonEntity: Name: NameFull: Su CC – PersonEntity: Name: NameFull: Hung CF – PersonEntity: Name: NameFull: Yang CC – PersonEntity: Name: NameFull: Lee JH – PersonEntity: Name: NameFull: Chung JG IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 0192415X Numbering: – Type: volume Value: 30 – Type: issue Value: 2/3 Titles: – TitleFull: American Journal of Chinese Medicine Type: main |
| ResultId | 1 |
