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Incidence of sight-threatening retinopathy in patients with type 2 diabetes in the Liverpool Diabetic Eye Study: a cohort study.

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Title: Incidence of sight-threatening retinopathy in patients with type 2 diabetes in the Liverpool Diabetic Eye Study: a cohort study.
Authors: Younis N (AUTHOR), Broadbent DM (AUTHOR), Vora JP (AUTHOR), Harding SP (AUTHOR), Younis, Naveed (AUTHOR), Broadbent, Deborah M (AUTHOR), Vora, Jiten P (AUTHOR), Harding, Simon P (AUTHOR), Liverpool Diabetic Eye Study (CORPORATE AUTHOR)
Source: Lancet. 1/18/2003, Vol. 361 Issue 9353, p195-200. 6p.
Abstract: Background: Incidence data on which to base targets and protocols for screening for sight-threatening diabetic retinopathy are few. We aimed to investigate yearly and cumulative incidence of any retinopathy, maculopathy, and sight-threatening diabetic retinopathy in patients with type 2 diabetes in an established systematic programme and to calculate optimum screening intervals according to retinopathy grade at baseline.Methods: We investigated all patients with type 2 diabetes registered with enrolled general practices (except those who were attending an ophthalmologist) who had retinopathy data available at baseline and at least one further screening event. To screen patients, we used non-stereoscopic three-field mydriatic photography and modified Wisconsin grading. Sight-threatening diabetic retinopathy was defined as moderate preproliferative retinopathy or worse, or clinically significant maculopathy in either or both eyes.Findings: Results were obtained from 20 570 screening events. Yearly incidence of sight-threatening diabetic retinopathy in patients without retinopathy at baseline was 0.3% (95% CI 0.1-0.5) in the first year, rising to 1.8% (1.2-2.5) in the fifth year; cumulative incidence at 5 years was 3.9% (2.8-5.0). Rates of progression to sight-threatening diabetic retinopathy in year 1 by baseline status were: background 5.0% (3.5-6.5), and mild preproliferative 15% (10.2-19.8). For a 95% probability of remaining free of sight-threatening diabetic retinopathy, mean screening intervals by baseline status were: no retinopathy 5.4 years (95% CI 4.7-6.3), background 1.0 years (0.7-1.3), and mild preproliferative 0.3 years (0.2-0.5).Interpretation: A 3-year screening interval could be safely adopted for patients with no retinopathy, but yearly or more frequent screening is needed for patients with higher grades of retinopathy. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Incidence of sight-threatening retinopathy in patients with type 2 diabetes in the Liverpool Diabetic Eye Study: a cohort study.
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  Data: <searchLink fieldCode="AR" term="%22Younis+N%22">Younis N</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Broadbent+DM%22">Broadbent DM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vora+JP%22">Vora JP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harding+SP%22">Harding SP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Younis%2C+Naveed%22">Younis, Naveed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Broadbent%2C+Deborah+M%22">Broadbent, Deborah M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vora%2C+Jiten+P%22">Vora, Jiten P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harding%2C+Simon+P%22">Harding, Simon P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liverpool+Diabetic+Eye+Study%22">Liverpool Diabetic Eye Study</searchLink> (CORPORATE AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 1/18/2003, Vol. 361 Issue 9353, p195-200. 6p.
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  Label: Abstract
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  Data: <bold>Background: </bold>Incidence data on which to base targets and protocols for screening for sight-threatening diabetic retinopathy are few. We aimed to investigate yearly and cumulative incidence of any retinopathy, maculopathy, and sight-threatening diabetic retinopathy in patients with type 2 diabetes in an established systematic programme and to calculate optimum screening intervals according to retinopathy grade at baseline.<bold>Methods: </bold>We investigated all patients with type 2 diabetes registered with enrolled general practices (except those who were attending an ophthalmologist) who had retinopathy data available at baseline and at least one further screening event. To screen patients, we used non-stereoscopic three-field mydriatic photography and modified Wisconsin grading. Sight-threatening diabetic retinopathy was defined as moderate preproliferative retinopathy or worse, or clinically significant maculopathy in either or both eyes.<bold>Findings: </bold>Results were obtained from 20 570 screening events. Yearly incidence of sight-threatening diabetic retinopathy in patients without retinopathy at baseline was 0.3% (95% CI 0.1-0.5) in the first year, rising to 1.8% (1.2-2.5) in the fifth year; cumulative incidence at 5 years was 3.9% (2.8-5.0). Rates of progression to sight-threatening diabetic retinopathy in year 1 by baseline status were: background 5.0% (3.5-6.5), and mild preproliferative 15% (10.2-19.8). For a 95% probability of remaining free of sight-threatening diabetic retinopathy, mean screening intervals by baseline status were: no retinopathy 5.4 years (95% CI 4.7-6.3), background 1.0 years (0.7-1.3), and mild preproliferative 0.3 years (0.2-0.5).<bold>Interpretation: </bold>A 3-year screening interval could be safely adopted for patients with no retinopathy, but yearly or more frequent screening is needed for patients with higher grades of retinopathy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: 1/18/2003
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