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Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme.

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Title: Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme.
Authors: Peters U (AUTHOR), Sinha R (AUTHOR), Chatterjee N (AUTHOR), Subar AF (AUTHOR), Ziegler RG (AUTHOR), Kulldorff M (AUTHOR), Bresalier R (AUTHOR), Weissfeld JL (AUTHOR), Flood A (AUTHOR), Schatzkin A (AUTHOR), Hayes RB (AUTHOR), Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team (CORPORATE AUTHOR), Peters, Ulrike (AUTHOR), Sinha, Rashmi (AUTHOR), Chatterjee, Nilanjan (AUTHOR), Subar, Amy F (AUTHOR), Ziegler, Regina G (AUTHOR), Kulldorff, Martin (AUTHOR), Bresalier, Robert (AUTHOR), Weissfeld, Joel L (AUTHOR)
Source: Lancet. 5/3/2003, Vol. 361 Issue 9368, p1491-1495. 5p.
Abstract: Background: Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial.Methods: We used a 137-item food frequency questionnaire to assess the relation of fibre intake and frequency of colorectal adenoma. The study was done within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a randomised controlled trial designed to investigate methods for early detection of cancer. In our analysis, we compared fibre intake of 33971 participants who were sigmoidoscopy-negative for polyps, with 3591 cases with at least one histologically verified adenoma in the distal large bowel (ie, descending colon, sigmoid colon, or rectum). Odds ratios were estimated by logistic regression analysis.Findings: High intakes of dietary fibre were associated with a lower risk of colorectal adenoma, after adjustment for potential dietary and non-dietary risk factors. Participants in the highest quintile of dietary fibre intake had a 27% (95% CI 14-38, p(trend)=0.002) lower risk of adenoma than those in the lowest quintile. The inverse association was strongest for fibre from grains and cereals and from fruits. Risks were similar for advanced and non-advanced adenoma. Risk of rectal adenoma was not significantly associated with fibre intake.Interpretation: Dietary fibre, particularly from grains, cereals, and fruits, was associated with decreased risk of distal colon adenoma. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme.
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  Data: <searchLink fieldCode="AR" term="%22Peters+U%22">Peters U</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sinha+R%22">Sinha R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chatterjee+N%22">Chatterjee N</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Subar+AF%22">Subar AF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ziegler+RG%22">Ziegler RG</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kulldorff+M%22">Kulldorff M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bresalier+R%22">Bresalier R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weissfeld+JL%22">Weissfeld JL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Flood+A%22">Flood A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schatzkin+A%22">Schatzkin A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hayes+RB%22">Hayes RB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial+Project+Team%22">Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team</searchLink> (CORPORATE AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peters%2C+Ulrike%22">Peters, Ulrike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sinha%2C+Rashmi%22">Sinha, Rashmi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chatterjee%2C+Nilanjan%22">Chatterjee, Nilanjan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Subar%2C+Amy+F%22">Subar, Amy F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ziegler%2C+Regina+G%22">Ziegler, Regina G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kulldorff%2C+Martin%22">Kulldorff, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bresalier%2C+Robert%22">Bresalier, Robert</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weissfeld%2C+Joel+L%22">Weissfeld, Joel L</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 5/3/2003, Vol. 361 Issue 9368, p1491-1495. 5p.
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  Data: <bold>Background: </bold>Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial.<bold>Methods: </bold>We used a 137-item food frequency questionnaire to assess the relation of fibre intake and frequency of colorectal adenoma. The study was done within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a randomised controlled trial designed to investigate methods for early detection of cancer. In our analysis, we compared fibre intake of 33971 participants who were sigmoidoscopy-negative for polyps, with 3591 cases with at least one histologically verified adenoma in the distal large bowel (ie, descending colon, sigmoid colon, or rectum). Odds ratios were estimated by logistic regression analysis.<bold>Findings: </bold>High intakes of dietary fibre were associated with a lower risk of colorectal adenoma, after adjustment for potential dietary and non-dietary risk factors. Participants in the highest quintile of dietary fibre intake had a 27% (95% CI 14-38, p(trend)=0.002) lower risk of adenoma than those in the lowest quintile. The inverse association was strongest for fibre from grains and cereals and from fruits. Risks were similar for advanced and non-advanced adenoma. Risk of rectal adenoma was not significantly associated with fibre intake.<bold>Interpretation: </bold>Dietary fibre, particularly from grains, cereals, and fruits, was associated with decreased risk of distal colon adenoma. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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