View in EDS HTML Full Text PDF Full Text

Management of suspected acute viral upper respiratory tract infection in children with intranasal sodium cromoglicate: a randomised controlled trial.

Saved in:
Bibliographic Details
Title: Management of suspected acute viral upper respiratory tract infection in children with intranasal sodium cromoglicate: a randomised controlled trial.
Authors: Butler CC (AUTHOR), Robling M (AUTHOR), Prout H (AUTHOR), Hood K (AUTHOR), Kinnersley P (AUTHOR), Butler, Chris C (AUTHOR), Robling, Mike (AUTHOR), Prout, Hayley (AUTHOR), Hood, Kerenza (AUTHOR), Kinnersley, Paul (AUTHOR)
Source: Lancet. 6/22/2002, Vol. 359 Issue 9324, p2153-2158. 6p.
Abstract: Background: Upper respiratory tract infection in children is one of the most frequent reasons for visiting a family doctor, and antibiotics are often prescribed inappropriately. Sodium cromoglicate inhibits the ICAM-1 molecule, which is the receptor for human rhinoviruses. We aimed to investigate whether intranasal cromoglicate shortens duration of infection of the upper respiratory tract. Methods: We randomly assigned 290 children diagnosed with suspected acute viral upper respiratory tract infection by their family doctor (137 boys, 153 girls; mean age 5.2 years [SD 3.39]) either intranasal 4% sodium cromoglicate spray or intranasal normal saline spray. Follow-up was by daily symptom diary for 2 weeks and by telephone. Canadian Acute Respiratory Illness and Flu Scale (CARIFS) score was the primary outcome measure. Findings: 195 patients returned symptom diaries, and 20 of these could not be included in the main analysis. 246 patients completed the telephone interview at week 1. There was no difference in recovery rate over the first week between the two groups, with the estimated difference in slope of log (CARIFS) being -0.01 (95% CI -0.05 to 0.03). There were no differences between the two groups in side-effects or re-consultation rates. 43 (17%) of 246 children with suspected acute viral upper respiratory tract infection went back to see their family doctor, and 220 (89%) of 246 were managed without prescription of antibiotics. Interpretation: Intranasal sodium cromoglicate is not a useful additional treatment for this infection. Our results further clarify the role of prescribed drugs for children with these frequent illnesses. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 106950248
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Management of suspected acute viral upper respiratory tract infection in children with intranasal sodium cromoglicate: a randomised controlled trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Butler+CC%22">Butler CC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robling+M%22">Robling M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prout+H%22">Prout H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hood+K%22">Hood K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kinnersley+P%22">Kinnersley P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Butler%2C+Chris+C%22">Butler, Chris C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robling%2C+Mike%22">Robling, Mike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prout%2C+Hayley%22">Prout, Hayley</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hood%2C+Kerenza%22">Hood, Kerenza</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kinnersley%2C+Paul%22">Kinnersley, Paul</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 6/22/2002, Vol. 359 Issue 9324, p2153-2158. 6p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>Upper respiratory tract infection in children is one of the most frequent reasons for visiting a family doctor, and antibiotics are often prescribed inappropriately. Sodium cromoglicate inhibits the ICAM-1 molecule, which is the receptor for human rhinoviruses. We aimed to investigate whether intranasal cromoglicate shortens duration of infection of the upper respiratory tract. <bold>Methods: </bold>We randomly assigned 290 children diagnosed with suspected acute viral upper respiratory tract infection by their family doctor (137 boys, 153 girls; mean age 5.2 years [SD 3.39]) either intranasal 4% sodium cromoglicate spray or intranasal normal saline spray. Follow-up was by daily symptom diary for 2 weeks and by telephone. Canadian Acute Respiratory Illness and Flu Scale (CARIFS) score was the primary outcome measure. <bold>Findings: </bold>195 patients returned symptom diaries, and 20 of these could not be included in the main analysis. 246 patients completed the telephone interview at week 1. There was no difference in recovery rate over the first week between the two groups, with the estimated difference in slope of log (CARIFS) being -0.01 (95% CI -0.05 to 0.03). There were no differences between the two groups in side-effects or re-consultation rates. 43 (17%) of 246 children with suspected acute viral upper respiratory tract infection went back to see their family doctor, and 220 (89%) of 246 were managed without prescription of antibiotics. <bold>Interpretation: </bold>Intranasal sodium cromoglicate is not a useful additional treatment for this infection. Our results further clarify the role of prescribed drugs for children with these frequent illnesses. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=106950248
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/s0140-6736(02)09091-8
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 2153
    Titles:
      – TitleFull: Management of suspected acute viral upper respiratory tract infection in children with intranasal sodium cromoglicate: a randomised controlled trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Butler CC
      – PersonEntity:
          Name:
            NameFull: Robling M
      – PersonEntity:
          Name:
            NameFull: Prout H
      – PersonEntity:
          Name:
            NameFull: Hood K
      – PersonEntity:
          Name:
            NameFull: Kinnersley P
      – PersonEntity:
          Name:
            NameFull: Butler, Chris C
      – PersonEntity:
          Name:
            NameFull: Robling, Mike
      – PersonEntity:
          Name:
            NameFull: Prout, Hayley
      – PersonEntity:
          Name:
            NameFull: Hood, Kerenza
      – PersonEntity:
          Name:
            NameFull: Kinnersley, Paul
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 22
              M: 06
              Text: 6/22/2002
              Type: published
              Y: 2002
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 359
            – Type: issue
              Value: 9324
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1