View in EDS HTML Full Text PDF Full Text

Paternal concentrations of dioxin and sex ratio of offspring.

Saved in:
Bibliographic Details
Title: Paternal concentrations of dioxin and sex ratio of offspring.
Authors: Mocarelli P (AUTHOR), Gerthoux PM (AUTHOR), Ferrari E (AUTHOR), Patterson DG Jr. (AUTHOR), Kieszak SM (AUTHOR), Brambilla P (AUTHOR), Vincoli N (AUTHOR), Signorini S (AUTHOR), Tramacere P (AUTHOR), Carreri V (AUTHOR), Sampson EJ (AUTHOR), Turner WE (AUTHOR), Needham LL (AUTHOR), Mocarelli, P (AUTHOR), Gerthoux, P M (AUTHOR), Ferrari, E (AUTHOR), Patterson, D G Jr (AUTHOR), Kieszak, S M (AUTHOR), Brambilla, P (AUTHOR), Vincoli, N (AUTHOR)
Source: Lancet. 05/27/2000, Vol. 355 Issue 9218, p1858-1863. 6p.
Abstract: Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin), is commonly considered the most toxic man-made substance. We have previously shown that high serum concentrations of TCDD in parents from Seveso, Italy, were linked to their having a relative increase in the number of female births after the parents exposure to a release of dioxin in 1976. We have continued the study to determine whether the parents' sex and/or age at exposure affected the sex ratio of their children. Methods: We measured the TCDD concentrations in serum samples from potentially exposed parents collected in 1976 and 1977, and investigated the sex ratio of their offspring. Findings: Serum samples were collected from 239 men and 296 women. 346 girls and 328 boys were born to potentially exposed parents between 1977 and 1996, showing an increased probability of female births (lower sex ratio) with increasing TCDD concentrations in the serum samples from the fathers (p=0.008). This effect starts at concentrations less than 20 ng per kg bodyweight. Fathers exposed when they were younger than 19 years of age sired significantly more girls than boys (sex ratio 0.38 [95% CI 0.30-0.47]). Interpretation: Exposure of men to TCDD is linked to a lowered male/female sex ratio in their offspring, which may persist for years after exposure. The median concentration of dioxin in fathers in this study is similar to doses that induce epididymal impairments in rats and is about 20 times the estimated average concentration of TCDD currently found in human beings in industrialised countries. These observations could have important public-health implications. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 107122045
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Paternal concentrations of dioxin and sex ratio of offspring.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Mocarelli+P%22">Mocarelli P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gerthoux+PM%22">Gerthoux PM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferrari+E%22">Ferrari E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patterson+DG+Jr%2E%22">Patterson DG Jr.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kieszak+SM%22">Kieszak SM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brambilla+P%22">Brambilla P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vincoli+N%22">Vincoli N</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Signorini+S%22">Signorini S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tramacere+P%22">Tramacere P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carreri+V%22">Carreri V</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sampson+EJ%22">Sampson EJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Turner+WE%22">Turner WE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Needham+LL%22">Needham LL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mocarelli%2C+P%22">Mocarelli, P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gerthoux%2C+P+M%22">Gerthoux, P M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferrari%2C+E%22">Ferrari, E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patterson%2C+D+G+Jr%22">Patterson, D G Jr</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kieszak%2C+S+M%22">Kieszak, S M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brambilla%2C+P%22">Brambilla, P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vincoli%2C+N%22">Vincoli, N</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 05/27/2000, Vol. 355 Issue 9218, p1858-1863. 6p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin), is commonly considered the most toxic man-made substance. We have previously shown that high serum concentrations of TCDD in parents from Seveso, Italy, were linked to their having a relative increase in the number of female births after the parents exposure to a release of dioxin in 1976. We have continued the study to determine whether the parents' sex and/or age at exposure affected the sex ratio of their children. <bold>Methods: </bold>We measured the TCDD concentrations in serum samples from potentially exposed parents collected in 1976 and 1977, and investigated the sex ratio of their offspring. <bold>Findings: </bold>Serum samples were collected from 239 men and 296 women. 346 girls and 328 boys were born to potentially exposed parents between 1977 and 1996, showing an increased probability of female births (lower sex ratio) with increasing TCDD concentrations in the serum samples from the fathers (p=0.008). This effect starts at concentrations less than 20 ng per kg bodyweight. Fathers exposed when they were younger than 19 years of age sired significantly more girls than boys (sex ratio 0.38 [95% CI 0.30-0.47]). <bold>Interpretation: </bold>Exposure of men to TCDD is linked to a lowered male/female sex ratio in their offspring, which may persist for years after exposure. The median concentration of dioxin in fathers in this study is similar to doses that induce epididymal impairments in rats and is about 20 times the estimated average concentration of TCDD currently found in human beings in industrialised countries. These observations could have important public-health implications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=107122045
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/s0140-6736(00)02290-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1858
    Titles:
      – TitleFull: Paternal concentrations of dioxin and sex ratio of offspring.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mocarelli P
      – PersonEntity:
          Name:
            NameFull: Gerthoux PM
      – PersonEntity:
          Name:
            NameFull: Ferrari E
      – PersonEntity:
          Name:
            NameFull: Patterson DG Jr.
      – PersonEntity:
          Name:
            NameFull: Kieszak SM
      – PersonEntity:
          Name:
            NameFull: Brambilla P
      – PersonEntity:
          Name:
            NameFull: Vincoli N
      – PersonEntity:
          Name:
            NameFull: Signorini S
      – PersonEntity:
          Name:
            NameFull: Tramacere P
      – PersonEntity:
          Name:
            NameFull: Carreri V
      – PersonEntity:
          Name:
            NameFull: Sampson EJ
      – PersonEntity:
          Name:
            NameFull: Turner WE
      – PersonEntity:
          Name:
            NameFull: Needham LL
      – PersonEntity:
          Name:
            NameFull: Mocarelli, P
      – PersonEntity:
          Name:
            NameFull: Gerthoux, P M
      – PersonEntity:
          Name:
            NameFull: Ferrari, E
      – PersonEntity:
          Name:
            NameFull: Patterson, D G Jr
      – PersonEntity:
          Name:
            NameFull: Kieszak, S M
      – PersonEntity:
          Name:
            NameFull: Brambilla, P
      – PersonEntity:
          Name:
            NameFull: Vincoli, N
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 27
              M: 05
              Text: 05/27/2000
              Type: published
              Y: 2000
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 355
            – Type: issue
              Value: 9218
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1